AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.

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Autores principales:	Jake F. Watson, Alexandra Pinggera, Hinze Ho, Ingo H. Greger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e9af46d449b42a3b228a2f6b64bac22
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spelling	oai:doaj.org-article:9e9af46d449b42a3b228a2f6b64bac222021-12-02T18:53:15ZAMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions10.1038/s41467-021-25281-42041-1723https://doaj.org/article/9e9af46d449b42a3b228a2f6b64bac222021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25281-4https://doaj.org/toc/2041-1723Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.Jake F. WatsonAlexandra PinggeraHinze HoIngo H. GregerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jake F. Watson Alexandra Pinggera Hinze Ho Ingo H. Greger AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
description	Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.
format	article
author	Jake F. Watson Alexandra Pinggera Hinze Ho Ingo H. Greger
author_facet	Jake F. Watson Alexandra Pinggera Hinze Ho Ingo H. Greger
author_sort	Jake F. Watson
title	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
title_short	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
title_full	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
title_fullStr	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
title_full_unstemmed	AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions
title_sort	ampa receptor anchoring at ca1 synapses is determined by n-terminal domain and tarp γ8 interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e9af46d449b42a3b228a2f6b64bac22
work_keys_str_mv	AT jakefwatson ampareceptoranchoringatca1synapsesisdeterminedbynterminaldomainandtarpg8interactions AT alexandrapinggera ampareceptoranchoringatca1synapsesisdeterminedbynterminaldomainandtarpg8interactions AT hinzeho ampareceptoranchoringatca1synapsesisdeterminedbynterminaldomainandtarpg8interactions AT ingohgreger ampareceptoranchoringatca1synapsesisdeterminedbynterminaldomainandtarpg8interactions
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AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

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