Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acetylation, increased homologous recombination and po...

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Autores principales:	Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
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spelling	oai:doaj.org-article:9e9b057abf944363949c648ff88a38f32021-11-08T11:12:32ZInhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function10.1038/s41467-021-26570-82041-1723https://doaj.org/article/9e9b057abf944363949c648ff88a38f32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26570-8https://doaj.org/toc/2041-1723Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acetylation, increased homologous recombination and potential synergy between radiation and HAT inhibition in CREBBP/EP300 mutant tumors.Manish KumarDavid MolkentineJessica MolkentineKathleen BridgesTongxin XieLiangpeng YangAndrew HefnerMeng GaoReshub BahriAnnika DhawanMitchell J. FrederickSahil SethMohamed AbdelhakiemBeth M. BeadleFaye JohnsonJing WangLi ShenTimothy HeffernanAakash ShethRobert L. FerrisJeffrey N. MyersCurtis R. PickeringHeath D. SkinnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manish Kumar David Molkentine Jessica Molkentine Kathleen Bridges Tongxin Xie Liangpeng Yang Andrew Hefner Meng Gao Reshub Bahri Annika Dhawan Mitchell J. Frederick Sahil Seth Mohamed Abdelhakiem Beth M. Beadle Faye Johnson Jing Wang Li Shen Timothy Heffernan Aakash Sheth Robert L. Ferris Jeffrey N. Myers Curtis R. Pickering Heath D. Skinner Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
description	Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acetylation, increased homologous recombination and potential synergy between radiation and HAT inhibition in CREBBP/EP300 mutant tumors.
format	article
author	Manish Kumar David Molkentine Jessica Molkentine Kathleen Bridges Tongxin Xie Liangpeng Yang Andrew Hefner Meng Gao Reshub Bahri Annika Dhawan Mitchell J. Frederick Sahil Seth Mohamed Abdelhakiem Beth M. Beadle Faye Johnson Jing Wang Li Shen Timothy Heffernan Aakash Sheth Robert L. Ferris Jeffrey N. Myers Curtis R. Pickering Heath D. Skinner
author_facet	Manish Kumar David Molkentine Jessica Molkentine Kathleen Bridges Tongxin Xie Liangpeng Yang Andrew Hefner Meng Gao Reshub Bahri Annika Dhawan Mitchell J. Frederick Sahil Seth Mohamed Abdelhakiem Beth M. Beadle Faye Johnson Jing Wang Li Shen Timothy Heffernan Aakash Sheth Robert L. Ferris Jeffrey N. Myers Curtis R. Pickering Heath D. Skinner
author_sort	Manish Kumar
title	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
title_short	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
title_full	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
title_fullStr	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
title_full_unstemmed	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
title_sort	inhibition of histone acetyltransferase function radiosensitizes crebbp/ep300 mutants via repression of homologous recombination, potentially targeting a gain of function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
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Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function

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