How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?

Abstract Several randomized controlled trials of anti-estrogens, such as tamoxifen and aromatase inhibitors, have demonstrated up to a 50–65% decrease in breast cancerincidence among high-risk women. Approximately 15% of women, age 35–79 years, in the U.S. meet criteria for breast cancer preventive...

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Autores principales:	Katherine D. Crew, Kathy S. Albain, Dawn L. Hershman, Joseph M. Unger, Shelly S. Lo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9e9b0c4255f248ec9c7a12bc8d55c04e
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spelling	oai:doaj.org-article:9e9b0c4255f248ec9c7a12bc8d55c04e2021-12-02T16:19:33ZHow do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?10.1038/s41523-017-0021-y2374-4677https://doaj.org/article/9e9b0c4255f248ec9c7a12bc8d55c04e2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0021-yhttps://doaj.org/toc/2374-4677Abstract Several randomized controlled trials of anti-estrogens, such as tamoxifen and aromatase inhibitors, have demonstrated up to a 50–65% decrease in breast cancerincidence among high-risk women. Approximately 15% of women, age 35–79 years, in the U.S. meet criteria for breast cancer preventive therapies, but uptake of these medications remain low. Explanations for this low uptake includelack of awareness of breast cancer risk status, insufficient knowledge about breast cancer preventive therapies among patients and physicians, and toxicity concerns. Increasing acceptance of pharmacologic breast cancer prevention will require effective communication of breast cancer risk, accurate representation about the potential benefits and side effects of anti-estrogens, targeting-specific high-risk populations most likely to benefit from preventive therapy, and minimizing the side effects of current anti-estrogens with novel administration and dosing options. One strategy to improve the uptake of chemoprevention strategies is to consider lessons learned from the use of drugs to prevent other chronic conditions, such as cardiovascular disease. Enhancing uptake and adherence to anti-estrogens for primary prevention holds promise for significantly reducing breast cancer incidence, however, this will require a significant change in our current clinical practice and stronger advocacy and awareness at the national level.Katherine D. CrewKathy S. AlbainDawn L. HershmanJoseph M. UngerShelly S. LoNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Katherine D. Crew Kathy S. Albain Dawn L. Hershman Joseph M. Unger Shelly S. Lo How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
description	Abstract Several randomized controlled trials of anti-estrogens, such as tamoxifen and aromatase inhibitors, have demonstrated up to a 50–65% decrease in breast cancerincidence among high-risk women. Approximately 15% of women, age 35–79 years, in the U.S. meet criteria for breast cancer preventive therapies, but uptake of these medications remain low. Explanations for this low uptake includelack of awareness of breast cancer risk status, insufficient knowledge about breast cancer preventive therapies among patients and physicians, and toxicity concerns. Increasing acceptance of pharmacologic breast cancer prevention will require effective communication of breast cancer risk, accurate representation about the potential benefits and side effects of anti-estrogens, targeting-specific high-risk populations most likely to benefit from preventive therapy, and minimizing the side effects of current anti-estrogens with novel administration and dosing options. One strategy to improve the uptake of chemoprevention strategies is to consider lessons learned from the use of drugs to prevent other chronic conditions, such as cardiovascular disease. Enhancing uptake and adherence to anti-estrogens for primary prevention holds promise for significantly reducing breast cancer incidence, however, this will require a significant change in our current clinical practice and stronger advocacy and awareness at the national level.
format	article
author	Katherine D. Crew Kathy S. Albain Dawn L. Hershman Joseph M. Unger Shelly S. Lo
author_facet	Katherine D. Crew Kathy S. Albain Dawn L. Hershman Joseph M. Unger Shelly S. Lo
author_sort	Katherine D. Crew
title	How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
title_short	How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
title_full	How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
title_fullStr	How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
title_full_unstemmed	How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
title_sort	how do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9e9b0c4255f248ec9c7a12bc8d55c04e
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How do we increase uptake of tamoxifen and other anti-estrogens for breast cancer prevention?

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