Characterization and mitigation of gene expression burden in mammalian cells

The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.

Guardado en:

Detalles Bibliográficos
Autores principales:	Timothy Frei, Federica Cella, Fabiana Tedeschi, Joaquín Gutiérrez, Guy-Bart Stan, Mustafa Khammash, Velia Siciliano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e9d2a9d032a4e53a995962e99e67a03
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e9d2a9d032a4e53a995962e99e67a03
record_format	dspace
spelling	oai:doaj.org-article:9e9d2a9d032a4e53a995962e99e67a032021-12-02T17:25:35ZCharacterization and mitigation of gene expression burden in mammalian cells10.1038/s41467-020-18392-x2041-1723https://doaj.org/article/9e9d2a9d032a4e53a995962e99e67a032020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18392-xhttps://doaj.org/toc/2041-1723The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.Timothy FreiFederica CellaFabiana TedeschiJoaquín GutiérrezGuy-Bart StanMustafa KhammashVelia SicilianoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano Characterization and mitigation of gene expression burden in mammalian cells
description	The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.
format	article
author	Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano
author_facet	Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano
author_sort	Timothy Frei
title	Characterization and mitigation of gene expression burden in mammalian cells
title_short	Characterization and mitigation of gene expression burden in mammalian cells
title_full	Characterization and mitigation of gene expression burden in mammalian cells
title_fullStr	Characterization and mitigation of gene expression burden in mammalian cells
title_full_unstemmed	Characterization and mitigation of gene expression burden in mammalian cells
title_sort	characterization and mitigation of gene expression burden in mammalian cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9e9d2a9d032a4e53a995962e99e67a03
work_keys_str_mv	AT timothyfrei characterizationandmitigationofgeneexpressionburdeninmammaliancells AT federicacella characterizationandmitigationofgeneexpressionburdeninmammaliancells AT fabianatedeschi characterizationandmitigationofgeneexpressionburdeninmammaliancells AT joaquingutierrez characterizationandmitigationofgeneexpressionburdeninmammaliancells AT guybartstan characterizationandmitigationofgeneexpressionburdeninmammaliancells AT mustafakhammash characterizationandmitigationofgeneexpressionburdeninmammaliancells AT veliasiciliano characterizationandmitigationofgeneexpressionburdeninmammaliancells
_version_	1718380926103191552

Characterization and mitigation of gene expression burden in mammalian cells

Ejemplares similares