Characterization and mitigation of gene expression burden in mammalian cells
The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.
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Auteurs principaux: | Timothy Frei, Federica Cella, Fabiana Tedeschi, Joaquín Gutiérrez, Guy-Bart Stan, Mustafa Khammash, Velia Siciliano |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
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Accès en ligne: | https://doaj.org/article/9e9d2a9d032a4e53a995962e99e67a03 |
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