In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

Abstract Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physici...

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Autores principales:	Jie Luo, Esra Abaci Turk, Carolina Bibbo, Borjan Gagoski, Drucilla J. Roberts, Mark Vangel, Clare M. Tempany-Afdhal, Carol Barnewolt, Judy Estroff, Arvind Palanisamy, William H. Barth, Chloe Zera, Norberto Malpica, Polina Golland, Elfar Adalsteinsson, Julian N. Robinson, Patricia Ellen Grant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ea4bf95181a41e0a2e39b3e0210c707
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spelling	oai:doaj.org-article:9ea4bf95181a41e0a2e39b3e0210c7072021-12-02T16:06:24ZIn Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study10.1038/s41598-017-03450-02045-2322https://doaj.org/article/9ea4bf95181a41e0a2e39b3e0210c7072017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03450-0https://doaj.org/toc/2045-2322Abstract Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential. In-utero BOLD MRI time series were acquired at 29 to 34 weeks gestational age. Maps of oxygen Time-To-Plateau (TTP) were obtained in the placentas by voxel-wise fitting of the time series. Fetal brain and liver volumes were measured based on structural MR images. After delivery, birth weights were obtained and placental pathological evaluations were performed. Mean placental TTP negatively correlated with fetal liver and brain volumes at the time of MRI as well as with birth weights. Mean placental TTP positively correlated with placental pathology. This study demonstrates the potential of BOLD MRI with maternal hyperoxia to quantify regional placental function in vivo.Jie LuoEsra Abaci TurkCarolina BibboBorjan GagoskiDrucilla J. RobertsMark VangelClare M. Tempany-AfdhalCarol BarnewoltJudy EstroffArvind PalanisamyWilliam H. BarthChloe ZeraNorberto MalpicaPolina GollandElfar AdalsteinssonJulian N. RobinsonPatricia Ellen GrantNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Luo Esra Abaci Turk Carolina Bibbo Borjan Gagoski Drucilla J. Roberts Mark Vangel Clare M. Tempany-Afdhal Carol Barnewolt Judy Estroff Arvind Palanisamy William H. Barth Chloe Zera Norberto Malpica Polina Golland Elfar Adalsteinsson Julian N. Robinson Patricia Ellen Grant In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
description	Abstract Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential. In-utero BOLD MRI time series were acquired at 29 to 34 weeks gestational age. Maps of oxygen Time-To-Plateau (TTP) were obtained in the placentas by voxel-wise fitting of the time series. Fetal brain and liver volumes were measured based on structural MR images. After delivery, birth weights were obtained and placental pathological evaluations were performed. Mean placental TTP negatively correlated with fetal liver and brain volumes at the time of MRI as well as with birth weights. Mean placental TTP positively correlated with placental pathology. This study demonstrates the potential of BOLD MRI with maternal hyperoxia to quantify regional placental function in vivo.
format	article
author	Jie Luo Esra Abaci Turk Carolina Bibbo Borjan Gagoski Drucilla J. Roberts Mark Vangel Clare M. Tempany-Afdhal Carol Barnewolt Judy Estroff Arvind Palanisamy William H. Barth Chloe Zera Norberto Malpica Polina Golland Elfar Adalsteinsson Julian N. Robinson Patricia Ellen Grant
author_facet	Jie Luo Esra Abaci Turk Carolina Bibbo Borjan Gagoski Drucilla J. Roberts Mark Vangel Clare M. Tempany-Afdhal Carol Barnewolt Judy Estroff Arvind Palanisamy William H. Barth Chloe Zera Norberto Malpica Polina Golland Elfar Adalsteinsson Julian N. Robinson Patricia Ellen Grant
author_sort	Jie Luo
title	In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
title_short	In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
title_full	In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
title_fullStr	In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
title_full_unstemmed	In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study
title_sort	in vivo quantification of placental insufficiency by bold mri: a human study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9ea4bf95181a41e0a2e39b3e0210c707
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In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

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