Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study

Bojan Pajic,1–3,5 Iraklis Vastardis,1,3 Brigitte Pajic-Eggspuehler,1 Zisis Gatzioufas,2 Farhad Hafezi2,4 1Swiss Eye Research Foundation, Eye Clinic ORASIS, Reinach, Switzerland; 2Division of Ophthalmology, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switze...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pajic B, Vastardis I, Pajic-Eggspuehler B, Gatzioufas Z, Hafezi F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9ea89fe711364c08be8119f1495a703d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ea89fe711364c08be8119f1495a703d
record_format	dspace
spelling	oai:doaj.org-article:9ea89fe711364c08be8119f1495a703d2021-12-02T01:52:07ZFemtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study1177-5483https://doaj.org/article/9ea89fe711364c08be8119f1495a703d2014-09-01T00:00:00Zhttp://www.dovepress.com/femtosecond-laser-versus-mechanical-microkeratome-assisted-flap-creati-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Bojan Pajic,1–3,5 Iraklis Vastardis,1,3 Brigitte Pajic-Eggspuehler,1 Zisis Gatzioufas,2 Farhad Hafezi2,4 1Swiss Eye Research Foundation, Eye Clinic ORASIS, Reinach, Switzerland; 2Division of Ophthalmology, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland; 3Eye Hospital VIDAR-ORASIS Swiss, University of Novi Sad, Faculty of Physics, Novi Sad, Serbia; 4Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 5Military Medical Academy, University of Defense, Belgrade, SerbiaPurpose: To compare a femtosecond laser with a microkeratome for flap creation during laser in situ keratomileusis (LASIK) in terms of flap thickness predictability and visual outcomes.Patients and methods: This was a prospective, randomized, masked, paired-eye study. Forty-four patients (34 females) who received bilateral LASIK were included. Patients were stratified by ocular dominance, and they then underwent randomization of flap creation using the femtosecond laser on one eye and undergoing the microkeratome procedure on the other one. The visual outcome differences between the corrected distance visual acuity (CDVA) at baseline and the uncorrected distance visual acuity (UDVA) on the first day postoperatively were set as the efficiency index for both groups. All visual acuity outcome results and the deviation of flap thickness were evaluated. P-values <0.05 were considered statistically significant.Results: The index of efficiency regarding the postoperative visual outcomes in the microkeratome group was lower (P<0.0001). This result was correlated with the difference between intended and achieved flap thickness (P=0.038; r=0.28), and a negative relationship in the regression analysis was confirmed (P<0.04; R2=0.1428). The UDVA in the microkeratome group improved significantly by the end of the first month (P<0.0271) in comparison to the baseline CDVA. The deviation between intended and postoperative flap thickness using either optical coherence pachymetry or Heidelberg Retinal Tomography II confocal microscopy was statistically significant (paired t-test; P<0.001) between the groups. The flap thickness deviation in the microkeratome group was higher. In the femtosecond laser group, the efficiency index was stable postoperatively (P=0.64) The UDVA improved significantly by the end of the first postoperative week (P=0.0043) in comparison to the baseline CDVA. Six months after surgery, improvement in the UDVA was significant in both groups (all P<0.001; one way analysis of variance).Conclusion: Femtosecond laser was superior to microkeratome-assisted LASIK in terms of flap thickness predictability and the speed of visual acuity recovery. A negative relationship in the regression analysis between increasing flap thickness deviation and visual acuity recovery was confirmed.Keywords: LASIK, femtosecond laser, flap predictability, microkeratomePajic BVastardis IPajic-Eggspuehler BGatzioufas ZHafezi FDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1883-1889 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Pajic B Vastardis I Pajic-Eggspuehler B Gatzioufas Z Hafezi F Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
description	Bojan Pajic,1–3,5 Iraklis Vastardis,1,3 Brigitte Pajic-Eggspuehler,1 Zisis Gatzioufas,2 Farhad Hafezi2,4 1Swiss Eye Research Foundation, Eye Clinic ORASIS, Reinach, Switzerland; 2Division of Ophthalmology, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland; 3Eye Hospital VIDAR-ORASIS Swiss, University of Novi Sad, Faculty of Physics, Novi Sad, Serbia; 4Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 5Military Medical Academy, University of Defense, Belgrade, SerbiaPurpose: To compare a femtosecond laser with a microkeratome for flap creation during laser in situ keratomileusis (LASIK) in terms of flap thickness predictability and visual outcomes.Patients and methods: This was a prospective, randomized, masked, paired-eye study. Forty-four patients (34 females) who received bilateral LASIK were included. Patients were stratified by ocular dominance, and they then underwent randomization of flap creation using the femtosecond laser on one eye and undergoing the microkeratome procedure on the other one. The visual outcome differences between the corrected distance visual acuity (CDVA) at baseline and the uncorrected distance visual acuity (UDVA) on the first day postoperatively were set as the efficiency index for both groups. All visual acuity outcome results and the deviation of flap thickness were evaluated. P-values <0.05 were considered statistically significant.Results: The index of efficiency regarding the postoperative visual outcomes in the microkeratome group was lower (P<0.0001). This result was correlated with the difference between intended and achieved flap thickness (P=0.038; r=0.28), and a negative relationship in the regression analysis was confirmed (P<0.04; R2=0.1428). The UDVA in the microkeratome group improved significantly by the end of the first month (P<0.0271) in comparison to the baseline CDVA. The deviation between intended and postoperative flap thickness using either optical coherence pachymetry or Heidelberg Retinal Tomography II confocal microscopy was statistically significant (paired t-test; P<0.001) between the groups. The flap thickness deviation in the microkeratome group was higher. In the femtosecond laser group, the efficiency index was stable postoperatively (P=0.64) The UDVA improved significantly by the end of the first postoperative week (P=0.0043) in comparison to the baseline CDVA. Six months after surgery, improvement in the UDVA was significant in both groups (all P<0.001; one way analysis of variance).Conclusion: Femtosecond laser was superior to microkeratome-assisted LASIK in terms of flap thickness predictability and the speed of visual acuity recovery. A negative relationship in the regression analysis between increasing flap thickness deviation and visual acuity recovery was confirmed.Keywords: LASIK, femtosecond laser, flap predictability, microkeratome
format	article
author	Pajic B Vastardis I Pajic-Eggspuehler B Gatzioufas Z Hafezi F
author_facet	Pajic B Vastardis I Pajic-Eggspuehler B Gatzioufas Z Hafezi F
author_sort	Pajic B
title	Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
title_short	Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
title_full	Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
title_fullStr	Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
title_full_unstemmed	Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study
title_sort	femtosecond laser versus mechanical microkeratome-assisted flap creation for lasik: a prospective, randomized, paired-eye study
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/9ea89fe711364c08be8119f1495a703d
work_keys_str_mv	AT pajicb femtosecondlaserversusmechanicalmicrokeratomeassistedflapcreationforlasikaprospectiverandomizedpairedeyestudy AT vastardisi femtosecondlaserversusmechanicalmicrokeratomeassistedflapcreationforlasikaprospectiverandomizedpairedeyestudy AT pajiceggspuehlerb femtosecondlaserversusmechanicalmicrokeratomeassistedflapcreationforlasikaprospectiverandomizedpairedeyestudy AT gatzioufasz femtosecondlaserversusmechanicalmicrokeratomeassistedflapcreationforlasikaprospectiverandomizedpairedeyestudy AT hafezif femtosecondlaserversusmechanicalmicrokeratomeassistedflapcreationforlasikaprospectiverandomizedpairedeyestudy
_version_	1718402858032824320

Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study

Ejemplares similares