Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling them to characterize the circadian ubiquitinome...

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Autores principales:	Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Che Stafford, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9eaa29ea46a94e44b8746ae5c1156fde
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spelling	oai:doaj.org-article:9eaa29ea46a94e44b8746ae5c1156fde2021-12-02T15:22:48ZData-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology10.1038/s41467-020-20509-12041-1723https://doaj.org/article/9eaa29ea46a94e44b8746ae5c1156fde2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20509-1https://doaj.org/toc/2041-1723Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling them to characterize the circadian ubiquitinome in human cells.Fynn M. HansenMaria C. TanzerFranziska BrüningIsabell BludauChe StaffordBrenda A. SchulmanMaria S. RoblesOzge KarayelMatthias MannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fynn M. Hansen Maria C. Tanzer Franziska Brüning Isabell Bludau Che Stafford Brenda A. Schulman Maria S. Robles Ozge Karayel Matthias Mann Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
description	Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling them to characterize the circadian ubiquitinome in human cells.
format	article
author	Fynn M. Hansen Maria C. Tanzer Franziska Brüning Isabell Bludau Che Stafford Brenda A. Schulman Maria S. Robles Ozge Karayel Matthias Mann
author_facet	Fynn M. Hansen Maria C. Tanzer Franziska Brüning Isabell Bludau Che Stafford Brenda A. Schulman Maria S. Robles Ozge Karayel Matthias Mann
author_sort	Fynn M. Hansen
title	Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
title_short	Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
title_full	Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
title_fullStr	Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
title_full_unstemmed	Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
title_sort	data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9eaa29ea46a94e44b8746ae5c1156fde
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Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

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