Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective

Chronic immunosuppression is associated with an increased risk of malignancy. The main objective of this study is to evaluate the incidence and effect of post-transplant malignancies (PTMs) following pancreas transplantation. The 348 first pancreas transplants performed between 1985 and 2015 were re...

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Autores principales:	Felix J. Krendl, Franka Messner, Claudia Bösmüller, Stefan Scheidl, Benno Cardini, Thomas Resch, Annemarie Weissenbacher, Rupert Oberhuber, Manuel Maglione, Stefan Schneeberger, Dietmar Öfner, Christian Margreiter
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	graft survival immunosuppression incidence malignancy pancreas transplantation Medicine R
Acceso en línea:	https://doaj.org/article/9eab85b1179e43a89e3ee730b81f6690
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spelling	oai:doaj.org-article:9eab85b1179e43a89e3ee730b81f66902021-11-11T17:29:16ZPost-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective10.3390/jcm102148102077-0383https://doaj.org/article/9eab85b1179e43a89e3ee730b81f66902021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4810https://doaj.org/toc/2077-0383Chronic immunosuppression is associated with an increased risk of malignancy. The main objective of this study is to evaluate the incidence and effect of post-transplant malignancies (PTMs) following pancreas transplantation. The 348 first pancreas transplants performed between 1985 and 2015 were retrospectively analyzed in this study. Incidences of PTMs, as well as patient and graft survival, were evaluated. Out of 348 patients, 71 (20.4%) developed a PTM. Median time to diagnosis was 130 months. Thirty-six patients (50.7%) developed skin cancers (four patients with melanoma, 32 with NMSCs). Solid organ malignancy occurred in 25 (35.2%), hematologic malignancy in ten patients (14.1%). Affected patients were transplanted earlier [2000 (IQR 1993−2004) vs. 2003 (IQR 1999−2008); <i>p</i> < 0.001]. No differences in induction therapy were seen, both groups demonstrated comparable patient and graft survival. Pancreas transplant recipients with solid organ and hematologic malignancies had a three- and six-fold increased hazard of death compared to those with skin cancers [aHR 3.04 (IQR 1.17–7.91); <i>p</i> = 0.023; aHR 6.07 (IQR 1.87–19.71); <i>p</i> = 0.003]. PTMs affect every fifth patient following pancreas transplantation. Skin cancers are the most common malignancies accounting for 50% of all PTMs. These results underscore the importance of close dermatologic follow-up.Felix J. KrendlFranka MessnerClaudia BösmüllerStefan ScheidlBenno CardiniThomas ReschAnnemarie WeissenbacherRupert OberhuberManuel MaglioneStefan SchneebergerDietmar ÖfnerChristian MargreiterMDPI AGarticlegraft survivalimmunosuppressionincidencemalignancypancreas transplantationMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4810, p 4810 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	graft survival immunosuppression incidence malignancy pancreas transplantation Medicine R
spellingShingle	graft survival immunosuppression incidence malignancy pancreas transplantation Medicine R Felix J. Krendl Franka Messner Claudia Bösmüller Stefan Scheidl Benno Cardini Thomas Resch Annemarie Weissenbacher Rupert Oberhuber Manuel Maglione Stefan Schneeberger Dietmar Öfner Christian Margreiter Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
description	Chronic immunosuppression is associated with an increased risk of malignancy. The main objective of this study is to evaluate the incidence and effect of post-transplant malignancies (PTMs) following pancreas transplantation. The 348 first pancreas transplants performed between 1985 and 2015 were retrospectively analyzed in this study. Incidences of PTMs, as well as patient and graft survival, were evaluated. Out of 348 patients, 71 (20.4%) developed a PTM. Median time to diagnosis was 130 months. Thirty-six patients (50.7%) developed skin cancers (four patients with melanoma, 32 with NMSCs). Solid organ malignancy occurred in 25 (35.2%), hematologic malignancy in ten patients (14.1%). Affected patients were transplanted earlier [2000 (IQR 1993−2004) vs. 2003 (IQR 1999−2008); <i>p</i> < 0.001]. No differences in induction therapy were seen, both groups demonstrated comparable patient and graft survival. Pancreas transplant recipients with solid organ and hematologic malignancies had a three- and six-fold increased hazard of death compared to those with skin cancers [aHR 3.04 (IQR 1.17–7.91); <i>p</i> = 0.023; aHR 6.07 (IQR 1.87–19.71); <i>p</i> = 0.003]. PTMs affect every fifth patient following pancreas transplantation. Skin cancers are the most common malignancies accounting for 50% of all PTMs. These results underscore the importance of close dermatologic follow-up.
format	article
author	Felix J. Krendl Franka Messner Claudia Bösmüller Stefan Scheidl Benno Cardini Thomas Resch Annemarie Weissenbacher Rupert Oberhuber Manuel Maglione Stefan Schneeberger Dietmar Öfner Christian Margreiter
author_facet	Felix J. Krendl Franka Messner Claudia Bösmüller Stefan Scheidl Benno Cardini Thomas Resch Annemarie Weissenbacher Rupert Oberhuber Manuel Maglione Stefan Schneeberger Dietmar Öfner Christian Margreiter
author_sort	Felix J. Krendl
title	Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
title_short	Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
title_full	Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
title_fullStr	Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
title_full_unstemmed	Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective
title_sort	post-transplant malignancies following pancreas transplantation: incidence and implications on long-term outcome from a single-center perspective
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9eab85b1179e43a89e3ee730b81f6690
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Post-Transplant Malignancies following Pancreas Transplantation: Incidence and Implications on Long-Term Outcome from a Single-Center Perspective

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