Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
In this work, through utilizing the mixed-ligand synthesis method, two coordination polymers (CPs) based on Co(II), namely, {[Co(μ-ppda)(μ-pbmeix)]·H2O}n (2) and [Co(μ-opda)(μ-pbmeix)0.5]n (1), have been triumphantly formed from 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix), a semi-rigid liga...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9eabfbb37c6a4b9eaddee4a36229c1f1 |
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| Sumario: | In this work, through utilizing the mixed-ligand synthesis method, two coordination polymers (CPs) based on Co(II), namely, {[Co(μ-ppda)(μ-pbmeix)]·H2O}n (2) and [Co(μ-opda)(μ-pbmeix)0.5]n (1), have been triumphantly formed from 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix), a semi-rigid ligand with Co(II) nitrate salts and distinct carboxylic acid co-ligands (o/ppda = 1,2-/1,4-phenylenediacetate). For treatment of pancreatic cancer, the as-generated compounds’ inhibitory activity against the viability of cancer cell was determined by the Cell Counting Kit-8 (CCK-8) assay. The above compounds’ suppression effect against the cells invasion and migration ability was investigated by the trans-well detection. The real time reverse transcription-polymerase chain reaction (RT-PCR) subsequently was employed to test the VEGF signaling pathway activation. Eventually, the cancer cells apoptosis levels after treating with above compound were assessed via detecting the BCL-2 protein expression level. Furthermore, results from molecular docking simulation indicate that complex 1 not only exhibits relatively lower affinity energy, but also forms more binding interactions in comparison to complex 2 when binding to a given target protein. Complex 1 was much superior to complex 2 on treating pancreatic cancer via suppressing the cancer cell invasion, migration and viability ability. |
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