Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer

In this work, through utilizing the mixed-ligand synthesis method, two coordination polymers (CPs) based on Co(II), namely, {[Co(μ-ppda)(μ-pbmeix)]·H2O}n (2) and [Co(μ-opda)(μ-pbmeix)0.5]n (1), have been triumphantly formed from 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix), a semi-rigid liga...

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Autores principales:	Fa-Zhao Li, Jun He, Su-Shun Liu, Le-Ping Yang, Dong Xue
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Coordination polymers Co complex CCK-8 assay Pancreatic cancer Molecular docking Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9eabfbb37c6a4b9eaddee4a36229c1f1
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spelling	oai:doaj.org-article:9eabfbb37c6a4b9eaddee4a36229c1f12021-11-30T04:14:48ZTherapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer1878-535210.1016/j.arabjc.2021.103572https://doaj.org/article/9eabfbb37c6a4b9eaddee4a36229c1f12022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005876https://doaj.org/toc/1878-5352In this work, through utilizing the mixed-ligand synthesis method, two coordination polymers (CPs) based on Co(II), namely, {[Co(μ-ppda)(μ-pbmeix)]·H2O}n (2) and [Co(μ-opda)(μ-pbmeix)0.5]n (1), have been triumphantly formed from 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix), a semi-rigid ligand with Co(II) nitrate salts and distinct carboxylic acid co-ligands (o/ppda = 1,2-/1,4-phenylenediacetate). For treatment of pancreatic cancer, the as-generated compounds’ inhibitory activity against the viability of cancer cell was determined by the Cell Counting Kit-8 (CCK-8) assay. The above compounds’ suppression effect against the cells invasion and migration ability was investigated by the trans-well detection. The real time reverse transcription-polymerase chain reaction (RT-PCR) subsequently was employed to test the VEGF signaling pathway activation. Eventually, the cancer cells apoptosis levels after treating with above compound were assessed via detecting the BCL-2 protein expression level. Furthermore, results from molecular docking simulation indicate that complex 1 not only exhibits relatively lower affinity energy, but also forms more binding interactions in comparison to complex 2 when binding to a given target protein. Complex 1 was much superior to complex 2 on treating pancreatic cancer via suppressing the cancer cell invasion, migration and viability ability.Fa-Zhao LiJun HeSu-Shun LiuLe-Ping YangDong XueElsevierarticleCoordination polymersCo complexCCK-8 assayPancreatic cancerMolecular dockingChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 2, Pp 103572- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coordination polymers Co complex CCK-8 assay Pancreatic cancer Molecular docking Chemistry QD1-999
spellingShingle	Coordination polymers Co complex CCK-8 assay Pancreatic cancer Molecular docking Chemistry QD1-999 Fa-Zhao Li Jun He Su-Shun Liu Le-Ping Yang Dong Xue Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
description	In this work, through utilizing the mixed-ligand synthesis method, two coordination polymers (CPs) based on Co(II), namely, {[Co(μ-ppda)(μ-pbmeix)]·H2O}n (2) and [Co(μ-opda)(μ-pbmeix)0.5]n (1), have been triumphantly formed from 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix), a semi-rigid ligand with Co(II) nitrate salts and distinct carboxylic acid co-ligands (o/ppda = 1,2-/1,4-phenylenediacetate). For treatment of pancreatic cancer, the as-generated compounds’ inhibitory activity against the viability of cancer cell was determined by the Cell Counting Kit-8 (CCK-8) assay. The above compounds’ suppression effect against the cells invasion and migration ability was investigated by the trans-well detection. The real time reverse transcription-polymerase chain reaction (RT-PCR) subsequently was employed to test the VEGF signaling pathway activation. Eventually, the cancer cells apoptosis levels after treating with above compound were assessed via detecting the BCL-2 protein expression level. Furthermore, results from molecular docking simulation indicate that complex 1 not only exhibits relatively lower affinity energy, but also forms more binding interactions in comparison to complex 2 when binding to a given target protein. Complex 1 was much superior to complex 2 on treating pancreatic cancer via suppressing the cancer cell invasion, migration and viability ability.
format	article
author	Fa-Zhao Li Jun He Su-Shun Liu Le-Ping Yang Dong Xue
author_facet	Fa-Zhao Li Jun He Su-Shun Liu Le-Ping Yang Dong Xue
author_sort	Fa-Zhao Li
title	Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
title_short	Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
title_full	Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
title_fullStr	Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
title_full_unstemmed	Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
title_sort	therapeutic effect of two co(ii) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/9eabfbb37c6a4b9eaddee4a36229c1f1
work_keys_str_mv	AT fazhaoli therapeuticeffectoftwocoiicoordinationpolymersbyinhibitingtumorcellproliferationandinvasiononpancreaticcancer AT junhe therapeuticeffectoftwocoiicoordinationpolymersbyinhibitingtumorcellproliferationandinvasiononpancreaticcancer AT sushunliu therapeuticeffectoftwocoiicoordinationpolymersbyinhibitingtumorcellproliferationandinvasiononpancreaticcancer AT lepingyang therapeuticeffectoftwocoiicoordinationpolymersbyinhibitingtumorcellproliferationandinvasiononpancreaticcancer AT dongxue therapeuticeffectoftwocoiicoordinationpolymersbyinhibitingtumorcellproliferationandinvasiononpancreaticcancer
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Therapeutic effect of two Co(II) coordination polymers by inhibiting tumor cell proliferation and invasion on pancreatic cancer

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