Therapeutic apheresis in autoimmune diseases

Rolf Bambauer,1 Reinhard Latza,2 Carolin Bambauer,3 Daniel Burgard,4 Ralf Schiel5 1Institute for Blood Purification, Homburg, 2Laboratorium of Medicine, St Ingbert, 3Main Hospital Darmstadt, Darmstadt, 4Herz Zentrum, Cardiology, Völklingen, 5Inselklinik Heringsdorf GmbH, Seeheilbad Heringsd...

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Autores principales:	Bambauer R, Latza R, Bambauer C, Burgard D, Schiel R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/9eac71ae87df42b38367d52688391f3b
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spelling	oai:doaj.org-article:9eac71ae87df42b38367d52688391f3b2021-12-02T09:47:18ZTherapeutic apheresis in autoimmune diseases1179-156Xhttps://doaj.org/article/9eac71ae87df42b38367d52688391f3b2013-11-01T00:00:00Zhttp://www.dovepress.com/therapeutic-apheresis-in-autoimmune-diseases-a14939https://doaj.org/toc/1179-156XRolf Bambauer,1 Reinhard Latza,2 Carolin Bambauer,3 Daniel Burgard,4 Ralf Schiel5 1Institute for Blood Purification, Homburg, 2Laboratorium of Medicine, St Ingbert, 3Main Hospital Darmstadt, Darmstadt, 4Herz Zentrum, Cardiology, Völklingen, 5Inselklinik Heringsdorf GmbH, Seeheilbad Heringsdorf, Germany Abstract: Systemic autoimmune diseases based on an immune pathogenesis produce autoantibodies and circulating immune complexes, which cause inflammation in the tissues of various organs. In most cases, these diseases have a bad prognosis without treatment. Therapeutic apheresis in combination with immunosuppressive therapies has led to a steady increase in survival rates over the last 35 years. Here we provide an overview of the most important pathogenic aspects indicating that therapeutic apheresis can be a supportive therapy in some systemic autoimmune diseases, such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, and inflammatory eye disease. With the introduction of novel and effective biologic agents, therapeutic apheresis is indicated only in severe cases, such as in rapid progression despite immunosuppressive therapy and/or biologic agents, and in patients with renal involvement, acute generalized vasculitis, thrombocytopenia, leucopenia, pulmonary, cardiac, or cerebral involvement. In mild forms of autoimmune disease, treatment with immunosuppressive therapies and/or biologic agents seems to be sufficient. The prognosis of autoimmune diseases with varying organ manifestations has improved considerably in recent years, due in part to very aggressive therapy schemes. Keywords: therapeutic apheresis, autoimmune diseases, systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, inflammatory eye diseaseBambauer RLatza RBambauer CBurgard DSchiel RDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2013, Iss default, Pp 93-103 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Bambauer R Latza R Bambauer C Burgard D Schiel R Therapeutic apheresis in autoimmune diseases
description	Rolf Bambauer,1 Reinhard Latza,2 Carolin Bambauer,3 Daniel Burgard,4 Ralf Schiel5 1Institute for Blood Purification, Homburg, 2Laboratorium of Medicine, St Ingbert, 3Main Hospital Darmstadt, Darmstadt, 4Herz Zentrum, Cardiology, Völklingen, 5Inselklinik Heringsdorf GmbH, Seeheilbad Heringsdorf, Germany Abstract: Systemic autoimmune diseases based on an immune pathogenesis produce autoantibodies and circulating immune complexes, which cause inflammation in the tissues of various organs. In most cases, these diseases have a bad prognosis without treatment. Therapeutic apheresis in combination with immunosuppressive therapies has led to a steady increase in survival rates over the last 35 years. Here we provide an overview of the most important pathogenic aspects indicating that therapeutic apheresis can be a supportive therapy in some systemic autoimmune diseases, such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, and inflammatory eye disease. With the introduction of novel and effective biologic agents, therapeutic apheresis is indicated only in severe cases, such as in rapid progression despite immunosuppressive therapy and/or biologic agents, and in patients with renal involvement, acute generalized vasculitis, thrombocytopenia, leucopenia, pulmonary, cardiac, or cerebral involvement. In mild forms of autoimmune disease, treatment with immunosuppressive therapies and/or biologic agents seems to be sufficient. The prognosis of autoimmune diseases with varying organ manifestations has improved considerably in recent years, due in part to very aggressive therapy schemes. Keywords: therapeutic apheresis, autoimmune diseases, systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, inflammatory eye disease
format	article
author	Bambauer R Latza R Bambauer C Burgard D Schiel R
author_facet	Bambauer R Latza R Bambauer C Burgard D Schiel R
author_sort	Bambauer R
title	Therapeutic apheresis in autoimmune diseases
title_short	Therapeutic apheresis in autoimmune diseases
title_full	Therapeutic apheresis in autoimmune diseases
title_fullStr	Therapeutic apheresis in autoimmune diseases
title_full_unstemmed	Therapeutic apheresis in autoimmune diseases
title_sort	therapeutic apheresis in autoimmune diseases
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/9eac71ae87df42b38367d52688391f3b
work_keys_str_mv	AT bambauerr therapeuticapheresisinautoimmunediseases AT latzar therapeuticapheresisinautoimmunediseases AT bambauerc therapeuticapheresisinautoimmunediseases AT burgardd therapeuticapheresisinautoimmunediseases AT schielr therapeuticapheresisinautoimmunediseases
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Therapeutic apheresis in autoimmune diseases

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