ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD

The aim of the study was to detect significant biochemical changes in antioxidant status during acute period of ischemic stroke in its various pathogenic subtypes in patients aged 45-74 years. The most important results were blood levels of ascorbic acid, malondialdehyde and free/ oxidized glutathio...

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Autor principal:	Y. L. Lukyanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	ischemic stroke oxidative stress antioxidants glutathione ascorbic acid malondialdehyde high performance liquid chromatography Science Q
Acceso en línea:	https://doaj.org/article/9eae2bef304d4522ad7edb75205ab1c7
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spelling	oai:doaj.org-article:9eae2bef304d4522ad7edb75205ab1c72021-11-23T06:14:36ZANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD2541-94202587-959610.12737/23747https://doaj.org/article/9eae2bef304d4522ad7edb75205ab1c72016-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/324https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the study was to detect significant biochemical changes in antioxidant status during acute period of ischemic stroke in its various pathogenic subtypes in patients aged 45-74 years. The most important results were blood levels of ascorbic acid, malondialdehyde and free/ oxidized glutathione ratio. Cardioembolic stroke was associated with: the reduced ascorbic acid level of 62-74 % comparable to control group; 5-times increased malondialdehyde level at the end of the first week of the disease; and also 50 % decreasing of cell antioxidant capacity comparable to control group and other stroke subtypes. In lacunary stroke minimal changes in antioxidant status were measured, possibly because of small size of brain damage. Positive clinical dynamics was followed by decreasing of free glutathione levels. It could be related with its previous significant expenditure in process of cell recovery in penumbra area. In case of favorable outcome all of the markers return to the levels which were comparable to control group. The differences in the dynamics of the cells antioxidant capacity and consumption of native antioxidants, the time from the onset of the disease, the severity of the clinical picture, depending on the stroke subtype, were revealed. Further research of this problem may help to create new methods of diagnostics and selective pharmacological correction of this pathology.Y. L. LukyanovaScientific Сentre for Family Health and Human Reproduction Problemsarticleischemic strokeoxidative stressantioxidantsglutathioneascorbic acidmalondialdehydehigh performance liquid chromatographyScienceQRUActa Biomedica Scientifica, Vol 1, Iss 6, Pp 76-81 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	ischemic stroke oxidative stress antioxidants glutathione ascorbic acid malondialdehyde high performance liquid chromatography Science Q
spellingShingle	ischemic stroke oxidative stress antioxidants glutathione ascorbic acid malondialdehyde high performance liquid chromatography Science Q Y. L. Lukyanova ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
description	The aim of the study was to detect significant biochemical changes in antioxidant status during acute period of ischemic stroke in its various pathogenic subtypes in patients aged 45-74 years. The most important results were blood levels of ascorbic acid, malondialdehyde and free/ oxidized glutathione ratio. Cardioembolic stroke was associated with: the reduced ascorbic acid level of 62-74 % comparable to control group; 5-times increased malondialdehyde level at the end of the first week of the disease; and also 50 % decreasing of cell antioxidant capacity comparable to control group and other stroke subtypes. In lacunary stroke minimal changes in antioxidant status were measured, possibly because of small size of brain damage. Positive clinical dynamics was followed by decreasing of free glutathione levels. It could be related with its previous significant expenditure in process of cell recovery in penumbra area. In case of favorable outcome all of the markers return to the levels which were comparable to control group. The differences in the dynamics of the cells antioxidant capacity and consumption of native antioxidants, the time from the onset of the disease, the severity of the clinical picture, depending on the stroke subtype, were revealed. Further research of this problem may help to create new methods of diagnostics and selective pharmacological correction of this pathology.
format	article
author	Y. L. Lukyanova
author_facet	Y. L. Lukyanova
author_sort	Y. L. Lukyanova
title	ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
title_short	ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
title_full	ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
title_fullStr	ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
title_full_unstemmed	ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD
title_sort	antioxidant status in various pathogenic subtypes of ischemic stroke in acute period
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/9eae2bef304d4522ad7edb75205ab1c7
work_keys_str_mv	AT yllukyanova antioxidantstatusinvariouspathogenicsubtypesofischemicstrokeinacuteperiod
_version_	1718417023260688384

ANTIOXIDANT STATUS IN VARIOUS PATHOGENIC SUBTYPES OF ISCHEMIC STROKE IN ACUTE PERIOD

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