Construction of a simple and selective electrochemical sensor based on Nafion/TiO2 for the voltammetric determination of olopatadine
A selective and facile voltammetric method based on titanium dioxide nanoparticles and Nafion (Nafion/TiO2 NPs) on the screen-printed electrode (SPE) was proposed for olopatadine determination. Followed by the synthesis of TiO2 nanoparticles, various methods, including high-resolution transmission...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
International Association of Physical Chemists (IAPC)
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9eb32d80f8164960af615841e713f880 |
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| Sumario: | A selective and facile voltammetric method based on titanium dioxide nanoparticles and Nafion (Nafion/TiO2 NPs) on the screen-printed electrode (SPE) was proposed for olopatadine determination. Followed by the synthesis of TiO2 nanoparticles, various methods, including high-resolution transmission electron microscopy (HR-TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray (EDX) Raman spectrum, and electrochemical impedance spectroscopy (EIS) were utilized to characterize the nanomaterials. Nafion/TiO2 on the screen-printed electrode (NFN/TiO2/SPE) was used to determine olopatadine in concentration ranges of 0.01 to 0.07 and 0.07 to 14.6 µM with a limit of quantification as low as 7.0 nM, via differential pulse voltammetry technique. The NFN/TiO2/SPE offered a high-performance ability to determine olopatadine in the eye drop sample with satisfactory recovery data of 98.2–99.0 %. Also, the developed electrode showed good reproducibility, repeatability, and high selectivity features. The obtained results indicate that NFN/TiO2/SPE could be utilized as an appropriate candidate for electrochemical olopatadine sensing.
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