Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma

Jianming Wu,&ast; Fangyan Zhou,&ast; Yu Gao Department of Dermatological, Yuying Children’s Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yu G...

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Autores principales:	Wu J, Zhou F, Gao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	infantile hemangioma 755-nm long-pulse alexandrite laser timolol maleate eye drops thick Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/9ebb8a98b7234b208034e0abce913cfe
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spelling	oai:doaj.org-article:9ebb8a98b7234b208034e0abce913cfe2021-11-09T18:40:35ZEfficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma1178-7015https://doaj.org/article/9ebb8a98b7234b208034e0abce913cfe2021-11-01T00:00:00Zhttps://www.dovepress.com/efficacy-evaluation-of-755-nm-long-pulse-alexandrite-laser-combined-wi-peer-reviewed-fulltext-article-CCIDhttps://doaj.org/toc/1178-7015Jianming Wu,&ast; Fangyan Zhou,&ast; Yu Gao Department of Dermatological, Yuying Children’s Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yu Gao Email 570875734@qq.comPurpose: Assessment of the clinical effectiveness and safety of 755-nm long-pulse alexandrite laser combined with 0.5% timolol maleate eye drops in treating thicker infantile hemangioma (IH).Materials and Methods: Retrospective analysis of IH treated with 755-nm long-pulse alexandrite laser and topical timolol in the Second Affiliated Hospital of Wenzhou Medical University from October 2019 to October 2020. Seventy-eight cases were included, with a five-week laser treatment interval. Treatment status was documented during the 35 weeks before each treatment, the effect was assessed at the visual analog scale (VAS), and side effects were recorded. During the 6-month follow-up period, the recurrence and residual skin lesions were monitored. The relationship between IH thickness, treatment duration and VAS was analyzed.Results: Among the 78 children with hemangioma, 4 children were treated with a combination of propranolol, fractional laser and cinnamyl alcohol injection due to poor curative effect. Finally, the lesions were effectively alleviated. At the 5th, 15th, 25th, and 35th weeks of treatment, the average VAS of 74 children were 3.56 ± 1.20, 4.61 ± 1.43, 5.63 ± 1.60, and 6.63 ± 1.72, respectively. We analyzed VAS in different thickness groups with Repeated Measures Analysis of Variance(RMANOVA). The results show that the VAS of the thickness 2– 3 mm and 3– 5mm groups were higher than the 5– 7mm and 7– 8mm groups (F group = 440.54, P < 0.05, F time = 448.31, P < 0.05). During the 6-month follow-up period, none of the 74 children relapsed and the residual skin lesions gradually vanished.Conclusion: Combined treatment of IHs with a 755-nm long-pulse alexandrite laser and 0.5% timolol maleate eye drops which has apparent clinical efficacy and safety reduce residual skin lesions and decrease the IH recurrence rate.Keywords: infantile hemangioma, 755-nm long-pulse alexandrite laser, timolol maleate eye drops, thickWu JZhou FGao YDove Medical Pressarticleinfantile hemangioma755-nm long-pulse alexandrite lasertimolol maleate eye dropsthickDermatologyRL1-803ENClinical, Cosmetic and Investigational Dermatology, Vol Volume 14, Pp 1621-1628 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	infantile hemangioma 755-nm long-pulse alexandrite laser timolol maleate eye drops thick Dermatology RL1-803
spellingShingle	infantile hemangioma 755-nm long-pulse alexandrite laser timolol maleate eye drops thick Dermatology RL1-803 Wu J Zhou F Gao Y Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
description	Jianming Wu,&ast; Fangyan Zhou,&ast; Yu Gao Department of Dermatological, Yuying Children’s Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yu Gao Email 570875734@qq.comPurpose: Assessment of the clinical effectiveness and safety of 755-nm long-pulse alexandrite laser combined with 0.5% timolol maleate eye drops in treating thicker infantile hemangioma (IH).Materials and Methods: Retrospective analysis of IH treated with 755-nm long-pulse alexandrite laser and topical timolol in the Second Affiliated Hospital of Wenzhou Medical University from October 2019 to October 2020. Seventy-eight cases were included, with a five-week laser treatment interval. Treatment status was documented during the 35 weeks before each treatment, the effect was assessed at the visual analog scale (VAS), and side effects were recorded. During the 6-month follow-up period, the recurrence and residual skin lesions were monitored. The relationship between IH thickness, treatment duration and VAS was analyzed.Results: Among the 78 children with hemangioma, 4 children were treated with a combination of propranolol, fractional laser and cinnamyl alcohol injection due to poor curative effect. Finally, the lesions were effectively alleviated. At the 5th, 15th, 25th, and 35th weeks of treatment, the average VAS of 74 children were 3.56 ± 1.20, 4.61 ± 1.43, 5.63 ± 1.60, and 6.63 ± 1.72, respectively. We analyzed VAS in different thickness groups with Repeated Measures Analysis of Variance(RMANOVA). The results show that the VAS of the thickness 2– 3 mm and 3– 5mm groups were higher than the 5– 7mm and 7– 8mm groups (F group = 440.54, P < 0.05, F time = 448.31, P < 0.05). During the 6-month follow-up period, none of the 74 children relapsed and the residual skin lesions gradually vanished.Conclusion: Combined treatment of IHs with a 755-nm long-pulse alexandrite laser and 0.5% timolol maleate eye drops which has apparent clinical efficacy and safety reduce residual skin lesions and decrease the IH recurrence rate.Keywords: infantile hemangioma, 755-nm long-pulse alexandrite laser, timolol maleate eye drops, thick
format	article
author	Wu J Zhou F Gao Y
author_facet	Wu J Zhou F Gao Y
author_sort	Wu J
title	Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
title_short	Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
title_full	Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
title_fullStr	Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
title_full_unstemmed	Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
title_sort	efficacy evaluation of 755-nm long-pulse alexandrite laser combined with 0.5% timolol maleate eye drops in the treatment of thicker infantile hemangioma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9ebb8a98b7234b208034e0abce913cfe
work_keys_str_mv	AT wuj efficacyevaluationof755nmlongpulsealexandritelasercombinedwith05timololmaleateeyedropsinthetreatmentofthickerinfantilehemangioma AT zhouf efficacyevaluationof755nmlongpulsealexandritelasercombinedwith05timololmaleateeyedropsinthetreatmentofthickerinfantilehemangioma AT gaoy efficacyevaluationof755nmlongpulsealexandritelasercombinedwith05timololmaleateeyedropsinthetreatmentofthickerinfantilehemangioma
_version_	1718440867672358912

Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma

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