Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia

Xinhua&nbsp;S Ren1,2,3, Lawrence Herz4,5, Shirley Qian1,2,3, Eric Smith3,4, Lewis&nbsp;E Kazis1,2,31The Center for the Assessment of Pharmaceutical Practices (CAPP), Boston University School of Public Health, Boston, MA, USA; 2Department of Health Policy and Management, Boston Univer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinhua&nbsp;S Ren, Lawrence Herz, Shirley Qian, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9ec0845f5f614e479778cf1c462db237
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ec0845f5f614e479778cf1c462db237
record_format	dspace
spelling	oai:doaj.org-article:9ec0845f5f614e479778cf1c462db2372021-12-02T00:58:43ZMeasurement of treatment adherence with antipsychotic agents in patients with schizophrenia1176-63281178-2021https://doaj.org/article/9ec0845f5f614e479778cf1c462db2372009-09-01T00:00:00Zhttp://www.dovepress.com/measurement-of-treatment-adherence-with-antipsychotic-agents-in-patien-a3589https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Xinhua&nbsp;S Ren1,2,3, Lawrence Herz4,5, Shirley Qian1,2,3, Eric Smith3,4, Lewis&nbsp;E Kazis1,2,31The Center for the Assessment of Pharmaceutical Practices (CAPP), Boston University School of Public Health, Boston, MA, USA; 2Department of Health Policy and Management, Boston University School of Public Health, Boston, MA, USA; 3Center for Health Quality, Outcomes, and Economic Research, Bedford Veterans Affairs Medical Center, Bedford, MA, USA; 4Division of Psychiatry, Boston University School of Medicine, Boston, MA, USA; 5Mental Health Service Line, Bedford VA Medical Center, Bedford, MA, USAAbstract: The importance of medication adherence in sustaining control of schizophrenic symptoms has generated a great deal of interest in comparing levels of treatment adherence with different antipsychotic agents. However, the bulk of the research has yielded results that are often inconsistent. In this prospective, observational study, we assessed the measurement properties of 3 commonly used, pharmacy-based measures of treatment adherence with antipsychotic agents in schizophrenia using data from the Veterans Health Administration during 2000 to 2005. Patients were selected if they were on antipsychotics and diagnosed with schizophrenia (N = 18,425). A gap of &ge;30 days (with no filled index medication) was used to define discontinuation of treatment as well as medication &ldquo;episodes,&rdquo; or the number of times a patient returned to the same index agent after discontinuation of treatment within a 1-year period. The study found that the 3 existing measures differed in their approaches in measuring treatment adherence, suggesting that studies using these different measures would generate different levels of treatment adherence across antipsychotic agents. Considering the measurement problems associated with each existing approach, we offered a new, medication episode-specific approach, which would provide a fairer comparison of the levels of treatment adherence across different antipsychotic agents.Keywords: medication adherence, antipsychotic agents, schizophrenia Xinhua&nbsp;S RenLawrence HerzShirley Qianet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 491-498 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xinhua&nbsp;S Ren Lawrence Herz Shirley Qian et al Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
description	Xinhua&nbsp;S Ren1,2,3, Lawrence Herz4,5, Shirley Qian1,2,3, Eric Smith3,4, Lewis&nbsp;E Kazis1,2,31The Center for the Assessment of Pharmaceutical Practices (CAPP), Boston University School of Public Health, Boston, MA, USA; 2Department of Health Policy and Management, Boston University School of Public Health, Boston, MA, USA; 3Center for Health Quality, Outcomes, and Economic Research, Bedford Veterans Affairs Medical Center, Bedford, MA, USA; 4Division of Psychiatry, Boston University School of Medicine, Boston, MA, USA; 5Mental Health Service Line, Bedford VA Medical Center, Bedford, MA, USAAbstract: The importance of medication adherence in sustaining control of schizophrenic symptoms has generated a great deal of interest in comparing levels of treatment adherence with different antipsychotic agents. However, the bulk of the research has yielded results that are often inconsistent. In this prospective, observational study, we assessed the measurement properties of 3 commonly used, pharmacy-based measures of treatment adherence with antipsychotic agents in schizophrenia using data from the Veterans Health Administration during 2000 to 2005. Patients were selected if they were on antipsychotics and diagnosed with schizophrenia (N = 18,425). A gap of &ge;30 days (with no filled index medication) was used to define discontinuation of treatment as well as medication &ldquo;episodes,&rdquo; or the number of times a patient returned to the same index agent after discontinuation of treatment within a 1-year period. The study found that the 3 existing measures differed in their approaches in measuring treatment adherence, suggesting that studies using these different measures would generate different levels of treatment adherence across antipsychotic agents. Considering the measurement problems associated with each existing approach, we offered a new, medication episode-specific approach, which would provide a fairer comparison of the levels of treatment adherence across different antipsychotic agents.Keywords: medication adherence, antipsychotic agents, schizophrenia
format	article
author	Xinhua&nbsp;S Ren Lawrence Herz Shirley Qian et al
author_facet	Xinhua&nbsp;S Ren Lawrence Herz Shirley Qian et al
author_sort	Xinhua&nbsp;S Ren
title	Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
title_short	Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
title_full	Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
title_fullStr	Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
title_full_unstemmed	Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
title_sort	measurement of treatment adherence with antipsychotic agents in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/9ec0845f5f614e479778cf1c462db237
work_keys_str_mv	AT xinhuaampnbspsren measurementoftreatmentadherencewithantipsychoticagentsinpatientswithschizophrenia AT lawrenceherz measurementoftreatmentadherencewithantipsychoticagentsinpatientswithschizophrenia AT shirleyqian measurementoftreatmentadherencewithantipsychoticagentsinpatientswithschizophrenia AT etal measurementoftreatmentadherencewithantipsychoticagentsinpatientswithschizophrenia
_version_	1718403399848820736

Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia

Ejemplares similares