Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome

Francisco Álvarez-Nava1,2, Marcia Racines3, Julia Witt1, Jéssica Guarderas1, María Estévez3,4, Roberto Lanes5 1Biological Sciences School, Faculty of Biological Sciences, Central University of Ecuador, Quito, Ecuador; 2Genetic Research Institute, Universit...

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Autores principales:	Álvarez-Nava F, Racines M, Witt J, Guarderas J, Estévez M, Lanes R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Anthropometric indexes body composition cardiometabolic risk metabolic syndrome obesity overweight Turner syndrome Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9ec1e3c49db14bf38d042e231438b0db
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spelling	oai:doaj.org-article:9ec1e3c49db14bf38d042e231438b0db2021-12-02T02:50:52ZAnthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome1178-7007https://doaj.org/article/9ec1e3c49db14bf38d042e231438b0db2019-09-01T00:00:00Zhttps://www.dovepress.com/anthropometric-variables-as-cardiovascular-risk-predictors-in-a-cohort-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Francisco Álvarez-Nava1,2, Marcia Racines3, Julia Witt1, Jéssica Guarderas1, María Estévez3,4, Roberto Lanes5 1Biological Sciences School, Faculty of Biological Sciences, Central University of Ecuador, Quito, Ecuador; 2Genetic Research Institute, University of Zulia, Maracaibo, Venezuela; 3Institute of Biomedicine Research, Central University of Ecuador; Quito, Ecuador; 4Ecuadorian Foundation in Support of Turner Syndrome, Quito, Ecuador; 5Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Caracas, VenezuelaCorrespondence: Francisco Álvarez-NavaBiological Sciences School, Faculty of Biological Sciences, Central University of Ecuador, Calle Iquique con Calle Sodiro Number N14-121, Parroquia San Blas, Quito, Pichincha 170113, EcuadorTel +593 252 8810Fax +593 252 8810Email fjalvarez@uce.edu.ecBackground and purpose: Excessive adiposity is associated with cardiometabolic complications in Turner syndrome (TS) subjects. Reference data for predictive anthropometric indices of overweight/obesity and metabolic syndrome (MetS) are lacking for subjects with TS. The purpose of this study was to identify the best anthropometric predictor of cardiometabolic risk in a Latin-American cohort of TS subjects.Patients and methods: This was a cross-sectional correlational study conducted in adult TS subjects (n=88) over the past seven years. Anthropometric parameters, body composition and biochemical variables were evaluated in a study and in a reference (n=57) group. Overweight/obesity and MetS were diagnosed using international consensus. The area under the ROC curve (AUC-ROC) was then used to determine the value of each anthropometric variable in predicting MetS or overweight/obesity.Results: The prevalence of MetS and overweight/obesity in TS subjects was 40% and 48%, respectively. All anthropometric and cardiometabolic variables were significantly increased in TS subjects when compared to the reference group, except for body mass index (BMI) and HDL-c. To detect MetS and overweight/obesity, waist to height ratio (WHtR) was found to have a higher correlation with cardiometabolic variables (TC, LDL-c, HDL-c levels and the LDL-c/HDL-c ratio), and to have a higher AUC-ROC and odds ratio than BMI, waist circumference (WC) and the waist to hip ratio (WHR).Conclusion: The prevalence of MetS and overweight/obesity is elevated in TS subjects. WHtR was the most useful variable in predicting the presence of MetS and overweight and obesity in this TS cohort. A combination of WHtR with BMI or with WC could have the best clinical utility in identifying adult TS subjects with overweight/obesity and MetS, respectively.Keywords: anthropometric indexes, body composition, cardiometabolic risk, metabolic syndrome, obesity, overweight, Turner syndromeÁlvarez-Nava FRacines MWitt JGuarderas JEstévez MLanes RDove Medical PressarticleAnthropometric indexesbody compositioncardiometabolic riskmetabolic syndromeobesityoverweightTurner syndromeSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1795-1809 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anthropometric indexes body composition cardiometabolic risk metabolic syndrome obesity overweight Turner syndrome Specialties of internal medicine RC581-951
spellingShingle	Anthropometric indexes body composition cardiometabolic risk metabolic syndrome obesity overweight Turner syndrome Specialties of internal medicine RC581-951 Álvarez-Nava F Racines M Witt J Guarderas J Estévez M Lanes R Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
description	Francisco Álvarez-Nava1,2, Marcia Racines3, Julia Witt1, Jéssica Guarderas1, María Estévez3,4, Roberto Lanes5 1Biological Sciences School, Faculty of Biological Sciences, Central University of Ecuador, Quito, Ecuador; 2Genetic Research Institute, University of Zulia, Maracaibo, Venezuela; 3Institute of Biomedicine Research, Central University of Ecuador; Quito, Ecuador; 4Ecuadorian Foundation in Support of Turner Syndrome, Quito, Ecuador; 5Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Caracas, VenezuelaCorrespondence: Francisco Álvarez-NavaBiological Sciences School, Faculty of Biological Sciences, Central University of Ecuador, Calle Iquique con Calle Sodiro Number N14-121, Parroquia San Blas, Quito, Pichincha 170113, EcuadorTel +593 252 8810Fax +593 252 8810Email fjalvarez@uce.edu.ecBackground and purpose: Excessive adiposity is associated with cardiometabolic complications in Turner syndrome (TS) subjects. Reference data for predictive anthropometric indices of overweight/obesity and metabolic syndrome (MetS) are lacking for subjects with TS. The purpose of this study was to identify the best anthropometric predictor of cardiometabolic risk in a Latin-American cohort of TS subjects.Patients and methods: This was a cross-sectional correlational study conducted in adult TS subjects (n=88) over the past seven years. Anthropometric parameters, body composition and biochemical variables were evaluated in a study and in a reference (n=57) group. Overweight/obesity and MetS were diagnosed using international consensus. The area under the ROC curve (AUC-ROC) was then used to determine the value of each anthropometric variable in predicting MetS or overweight/obesity.Results: The prevalence of MetS and overweight/obesity in TS subjects was 40% and 48%, respectively. All anthropometric and cardiometabolic variables were significantly increased in TS subjects when compared to the reference group, except for body mass index (BMI) and HDL-c. To detect MetS and overweight/obesity, waist to height ratio (WHtR) was found to have a higher correlation with cardiometabolic variables (TC, LDL-c, HDL-c levels and the LDL-c/HDL-c ratio), and to have a higher AUC-ROC and odds ratio than BMI, waist circumference (WC) and the waist to hip ratio (WHR).Conclusion: The prevalence of MetS and overweight/obesity is elevated in TS subjects. WHtR was the most useful variable in predicting the presence of MetS and overweight and obesity in this TS cohort. A combination of WHtR with BMI or with WC could have the best clinical utility in identifying adult TS subjects with overweight/obesity and MetS, respectively.Keywords: anthropometric indexes, body composition, cardiometabolic risk, metabolic syndrome, obesity, overweight, Turner syndrome
format	article
author	Álvarez-Nava F Racines M Witt J Guarderas J Estévez M Lanes R
author_facet	Álvarez-Nava F Racines M Witt J Guarderas J Estévez M Lanes R
author_sort	Álvarez-Nava F
title	Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
title_short	Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
title_full	Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
title_fullStr	Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
title_full_unstemmed	Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome
title_sort	anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with turner syndrome
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9ec1e3c49db14bf38d042e231438b0db
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Anthropometric variables as cardiovascular risk predictors in a cohort of adult subjects with Turner syndrome

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