Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lourdes Balcázar-Hernandez, Lourdes Basurto, Leticia Manuel-Apolinar, Sara Vega-García, Norma Basurto-Acevedo, Carlos Martínez-Murillo, Rosalinda Sánchez-Arenas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adiponectin osteocalcin irisin FGF-21 MCP-1 obesity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9ec50f3555f54d86b753f9a9370c75d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ec50f3555f54d86b753f9a9370c75d5
record_format	dspace
spelling	oai:doaj.org-article:9ec50f3555f54d86b753f9a9370c75d52021-11-25T18:20:49ZPattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?10.3390/metabo111107712218-1989https://doaj.org/article/9ec50f3555f54d86b753f9a9370c75d52021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/771https://doaj.org/toc/2218-1989Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; <i>p</i> = 0.047); adiponectin with BMI (r = −0.217; <i>p</i> = 0.001), insulin (r = −0.415; <i>p</i> = 0.0001), HOMA-IR (r = −0.429; <i>p</i> = 0.0001), and VAT (r = −0.134; <i>p</i> = 0.025); irisin with BMI (r = 0.604; <i>p</i> = 0.001), insulin (r = 0.446; <i>p</i> = 0.0001), HOMA-IR (r = 0.452; <i>p</i> = 0.0001), and VAT (r = 0.645; <i>p</i> = 0.0001); FGF−21 with insulin (r = −0.337; <i>p</i>= 0.030) and HOMA-IR (r = −0.341; <i>p</i> = 0.03); and MCP-1 with BMI (r = 0.481; <i>p</i> = 0.0001), VAT (r = 0.497; <i>p</i> = 0.001), insulin (r = 0.298; <i>p</i>= 0.001), and HOMA-IR (r = 0.255; <i>p</i> = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (<sub>95%</sub>CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.Lourdes Balcázar-HernandezLourdes BasurtoLeticia Manuel-ApolinarSara Vega-GarcíaNorma Basurto-AcevedoCarlos Martínez-MurilloRosalinda Sánchez-ArenasMDPI AGarticleadiponectinosteocalcinirisinFGF-21MCP-1obesityMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 771, p 771 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin osteocalcin irisin FGF-21 MCP-1 obesity Microbiology QR1-502
spellingShingle	adiponectin osteocalcin irisin FGF-21 MCP-1 obesity Microbiology QR1-502 Lourdes Balcázar-Hernandez Lourdes Basurto Leticia Manuel-Apolinar Sara Vega-García Norma Basurto-Acevedo Carlos Martínez-Murillo Rosalinda Sánchez-Arenas Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
description	Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; <i>p</i> = 0.047); adiponectin with BMI (r = −0.217; <i>p</i> = 0.001), insulin (r = −0.415; <i>p</i> = 0.0001), HOMA-IR (r = −0.429; <i>p</i> = 0.0001), and VAT (r = −0.134; <i>p</i> = 0.025); irisin with BMI (r = 0.604; <i>p</i> = 0.001), insulin (r = 0.446; <i>p</i> = 0.0001), HOMA-IR (r = 0.452; <i>p</i> = 0.0001), and VAT (r = 0.645; <i>p</i> = 0.0001); FGF−21 with insulin (r = −0.337; <i>p</i>= 0.030) and HOMA-IR (r = −0.341; <i>p</i> = 0.03); and MCP-1 with BMI (r = 0.481; <i>p</i> = 0.0001), VAT (r = 0.497; <i>p</i> = 0.001), insulin (r = 0.298; <i>p</i>= 0.001), and HOMA-IR (r = 0.255; <i>p</i> = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (<sub>95%</sub>CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.
format	article
author	Lourdes Balcázar-Hernandez Lourdes Basurto Leticia Manuel-Apolinar Sara Vega-García Norma Basurto-Acevedo Carlos Martínez-Murillo Rosalinda Sánchez-Arenas
author_facet	Lourdes Balcázar-Hernandez Lourdes Basurto Leticia Manuel-Apolinar Sara Vega-García Norma Basurto-Acevedo Carlos Martínez-Murillo Rosalinda Sánchez-Arenas
author_sort	Lourdes Balcázar-Hernandez
title	Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
title_short	Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
title_full	Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
title_fullStr	Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
title_full_unstemmed	Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
title_sort	pattern of adiponectin, osteocalcin, irisin, fgf-21, and mcp-1 according to the body size phenotype: could they be markers of metabolic health in mexican-mestizo middle-aged women?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ec50f3555f54d86b753f9a9370c75d5
work_keys_str_mv	AT lourdesbalcazarhernandez patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT lourdesbasurto patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT leticiamanuelapolinar patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT saravegagarcia patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT normabasurtoacevedo patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT carlosmartinezmurillo patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen AT rosalindasanchezarenas patternofadiponectinosteocalcinirisinfgf21andmcp1accordingtothebodysizephenotypecouldtheybemarkersofmetabolichealthinmexicanmestizomiddleagedwomen
_version_	1718411335606206464

Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Ejemplares similares