Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

Background: We aimed to evaluate the prognostic role of metabolic parameters on baseline F-18 fluorodeoxyglucose (FDG) PET/CT in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Methods: We retrospectively reviewed patients who were diagnosed with nonme...

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Autores principales:	Hojin Cho, Soyoung Kim, Kwanhyeong Jo, Yong Hyu Jeong, Won Jun Kang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oropharyngeal carcinoma prognosis FDG PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9ec60052de25475eb7dea9ad136e98bf
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spelling	oai:doaj.org-article:9ec60052de25475eb7dea9ad136e98bf2021-11-11T15:34:11ZTumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma10.3390/cancers132155382072-6694https://doaj.org/article/9ec60052de25475eb7dea9ad136e98bf2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5538https://doaj.org/toc/2072-6694Background: We aimed to evaluate the prognostic role of metabolic parameters on baseline F-18 fluorodeoxyglucose (FDG) PET/CT in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Methods: We retrospectively reviewed patients who were diagnosed with nonmetastatic HPV-related OPSCC using the 8th TNM staging system from 2010 to 2015 and underwent baseline F-18 FDG PET/CT. Tumor SUV<sub>max</sub> to liver SUV<sub>mean</sub> ratio (SUV<sub>max</sub>-TLR), metabolic tumor volume (MTV), tumor total lesion glycolysis to liver SUV<sub>mean</sub> ratio (TLG-TLR), and coefficient of variation (CV) of the primary tumor were measured. Patients were primarily treated with surgery or radiotherapy. Endpoints were progression-free survival (PFS) and overall survival (OS). Results: Ninety consecutive patients (male, 72; female, 18) were enrolled. They were followed up for a median of 77.4 months (interquartile range, 48.4–106.4). Sixteen patients progressed, and 13 died. Multivariate analysis revealed that patients with advanced age, overall stage, and higher SUV<sub>max</sub>-TLR or CV had poorer PFS and OS. Conclusion: Higher SUV<sub>max</sub>-TLR and CV of the primary tumor on baseline F-18 FDG PET/CT were associated with poorer PFS and OS in patients with nonmetastatic HPV-related OPSCC. Further study is warranted to address the possible implications of F-18 FDG PET/CT on treatment de-intensification in these patients.Hojin ChoSoyoung KimKwanhyeong JoYong Hyu JeongWon Jun KangMDPI AGarticleoropharyngeal carcinomaprognosisFDGPET/CTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5538, p 5538 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oropharyngeal carcinoma prognosis FDG PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	oropharyngeal carcinoma prognosis FDG PET/CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hojin Cho Soyoung Kim Kwanhyeong Jo Yong Hyu Jeong Won Jun Kang Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
description	Background: We aimed to evaluate the prognostic role of metabolic parameters on baseline F-18 fluorodeoxyglucose (FDG) PET/CT in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Methods: We retrospectively reviewed patients who were diagnosed with nonmetastatic HPV-related OPSCC using the 8th TNM staging system from 2010 to 2015 and underwent baseline F-18 FDG PET/CT. Tumor SUV<sub>max</sub> to liver SUV<sub>mean</sub> ratio (SUV<sub>max</sub>-TLR), metabolic tumor volume (MTV), tumor total lesion glycolysis to liver SUV<sub>mean</sub> ratio (TLG-TLR), and coefficient of variation (CV) of the primary tumor were measured. Patients were primarily treated with surgery or radiotherapy. Endpoints were progression-free survival (PFS) and overall survival (OS). Results: Ninety consecutive patients (male, 72; female, 18) were enrolled. They were followed up for a median of 77.4 months (interquartile range, 48.4–106.4). Sixteen patients progressed, and 13 died. Multivariate analysis revealed that patients with advanced age, overall stage, and higher SUV<sub>max</sub>-TLR or CV had poorer PFS and OS. Conclusion: Higher SUV<sub>max</sub>-TLR and CV of the primary tumor on baseline F-18 FDG PET/CT were associated with poorer PFS and OS in patients with nonmetastatic HPV-related OPSCC. Further study is warranted to address the possible implications of F-18 FDG PET/CT on treatment de-intensification in these patients.
format	article
author	Hojin Cho Soyoung Kim Kwanhyeong Jo Yong Hyu Jeong Won Jun Kang
author_facet	Hojin Cho Soyoung Kim Kwanhyeong Jo Yong Hyu Jeong Won Jun Kang
author_sort	Hojin Cho
title	Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
title_short	Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
title_full	Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
title_fullStr	Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
title_full_unstemmed	Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
title_sort	tumor glucose metabolism and its heterogeneity on f-18 fdg pet/ct provide better prognostication in nonmetastatic human papillomavirus-related oropharyngeal squamous cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ec60052de25475eb7dea9ad136e98bf
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Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

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