Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study
Background and Aims: Cholecystectomy is the “gold standard” for treating diseases of the gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), liver fibrosis or cirrhosis, are major causes of morbidity and mortality across the world. However, the association between cholecystectomy an...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:9ec66f670ed74c91b86d196e8408eed42021-12-01T16:54:48ZAssociation of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study2296-858X10.3389/fmed.2021.787777https://doaj.org/article/9ec66f670ed74c91b86d196e8408eed42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.787777/fullhttps://doaj.org/toc/2296-858XBackground and Aims: Cholecystectomy is the “gold standard” for treating diseases of the gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), liver fibrosis or cirrhosis, are major causes of morbidity and mortality across the world. However, the association between cholecystectomy and these diseases is still unclear. We assessed the association among US adults and examined the possible risk factors.Methods: This cross-sectional study used data from 2017 to 2018 National Health and Nutrition Examination Survey, a population-based nationally representative sample of US. Liver fibrosis and cirrhosis were defined by median stiffness, which was assessed by transient elastography. Furthermore, patients who had undergone cholecystectomy were identified based on the questionnaire. In addition, Propensity Score Matching (PSM, 1:1) was performed based on gender, age, body mass index (BMI) and diabetes.Results: Of the 4,497 included participants, cholecystectomy was associated with 60.0% higher risk of liver fibrosis (OR:1.600;95% CI:1.278–2.002), and 73.3% higher risk of liver cirrhosis (OR:1.733, 95% CI:1.076–2.792). After PSM based on age, gender, BMI group and history of diabetes, cholecystectomy was associated with 139.3% higher risk of liver fibrosis (OR: 2.393;95% CI: 1.738–3.297), and 228.7% higher risk of liver cirrhosis (OR: 3.287, 95% CI: 1.496–7.218).Conclusions: The present study showed that cholecystectomy is positively associated with liver fibrosis and cirrhosis in US adults. The discovery of these risk factors therefore provides new insights on the prevention of NAFLD, liver fibrosis, and cirrhosis.Zhi-Qin XieHong-Xia LiWen-Liang TanLei YangXiao-Wu MaWen-Xin LiQing-Bin WangChang-Zhen ShangYa-Jin ChenFrontiers Media S.A.articlecholecystectomynon-alcoholic fatty liver diseaseliver fibrosisliver cirrhosisassociationMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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EN |
| topic |
cholecystectomy non-alcoholic fatty liver disease liver fibrosis liver cirrhosis association Medicine (General) R5-920 |
| spellingShingle |
cholecystectomy non-alcoholic fatty liver disease liver fibrosis liver cirrhosis association Medicine (General) R5-920 Zhi-Qin Xie Hong-Xia Li Wen-Liang Tan Lei Yang Xiao-Wu Ma Wen-Xin Li Qing-Bin Wang Chang-Zhen Shang Ya-Jin Chen Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| description |
Background and Aims: Cholecystectomy is the “gold standard” for treating diseases of the gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), liver fibrosis or cirrhosis, are major causes of morbidity and mortality across the world. However, the association between cholecystectomy and these diseases is still unclear. We assessed the association among US adults and examined the possible risk factors.Methods: This cross-sectional study used data from 2017 to 2018 National Health and Nutrition Examination Survey, a population-based nationally representative sample of US. Liver fibrosis and cirrhosis were defined by median stiffness, which was assessed by transient elastography. Furthermore, patients who had undergone cholecystectomy were identified based on the questionnaire. In addition, Propensity Score Matching (PSM, 1:1) was performed based on gender, age, body mass index (BMI) and diabetes.Results: Of the 4,497 included participants, cholecystectomy was associated with 60.0% higher risk of liver fibrosis (OR:1.600;95% CI:1.278–2.002), and 73.3% higher risk of liver cirrhosis (OR:1.733, 95% CI:1.076–2.792). After PSM based on age, gender, BMI group and history of diabetes, cholecystectomy was associated with 139.3% higher risk of liver fibrosis (OR: 2.393;95% CI: 1.738–3.297), and 228.7% higher risk of liver cirrhosis (OR: 3.287, 95% CI: 1.496–7.218).Conclusions: The present study showed that cholecystectomy is positively associated with liver fibrosis and cirrhosis in US adults. The discovery of these risk factors therefore provides new insights on the prevention of NAFLD, liver fibrosis, and cirrhosis. |
| format |
article |
| author |
Zhi-Qin Xie Hong-Xia Li Wen-Liang Tan Lei Yang Xiao-Wu Ma Wen-Xin Li Qing-Bin Wang Chang-Zhen Shang Ya-Jin Chen |
| author_facet |
Zhi-Qin Xie Hong-Xia Li Wen-Liang Tan Lei Yang Xiao-Wu Ma Wen-Xin Li Qing-Bin Wang Chang-Zhen Shang Ya-Jin Chen |
| author_sort |
Zhi-Qin Xie |
| title |
Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| title_short |
Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| title_full |
Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| title_fullStr |
Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| title_full_unstemmed |
Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study |
| title_sort |
association of cholecystectomy with liver fibrosis and cirrhosis among adults in the usa: a population-based propensity score-matched study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9ec66f670ed74c91b86d196e8408eed4 |
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