Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells

Abstract Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intra...

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Autores principales:	Sang-Woo Kim, Yeon Kyung Lee, Sang-Hyun Kim, Jun-Young Park, Dong Un Lee, Jungil Choi, Jeong Hee Hong, Sanghyo Kim, Dongwoo Khang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ec9053b99384ff5a15769de5c42b18f
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spelling	oai:doaj.org-article:9ec9053b99384ff5a15769de5c42b18f2021-12-02T15:05:58ZCovalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells10.1038/s41598-017-06796-72045-2322https://doaj.org/article/9ec9053b99384ff5a15769de5c42b18f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06796-7https://doaj.org/toc/2045-2322Abstract Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The types of nano conjugation modulated intracellular dynamics associated with differential impact on anti-cancer efficacy, but also induced differential cytotoxicity on cancer versus normal cells. In conclusion, this study demonstrated the importance of selecting the appropriate type of nano-conjugation for delivering organelle specific, active chemotherapeutic agents through controlled intracellular trafficking.Sang-Woo KimYeon Kyung LeeSang-Hyun KimJun-Young ParkDong Un LeeJungil ChoiJeong Hee HongSanghyo KimDongwoo KhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang-Woo Kim Yeon Kyung Lee Sang-Hyun Kim Jun-Young Park Dong Un Lee Jungil Choi Jeong Hee Hong Sanghyo Kim Dongwoo Khang Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
description	Abstract Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The types of nano conjugation modulated intracellular dynamics associated with differential impact on anti-cancer efficacy, but also induced differential cytotoxicity on cancer versus normal cells. In conclusion, this study demonstrated the importance of selecting the appropriate type of nano-conjugation for delivering organelle specific, active chemotherapeutic agents through controlled intracellular trafficking.
format	article
author	Sang-Woo Kim Yeon Kyung Lee Sang-Hyun Kim Jun-Young Park Dong Un Lee Jungil Choi Jeong Hee Hong Sanghyo Kim Dongwoo Khang
author_facet	Sang-Woo Kim Yeon Kyung Lee Sang-Hyun Kim Jun-Young Park Dong Un Lee Jungil Choi Jeong Hee Hong Sanghyo Kim Dongwoo Khang
author_sort	Sang-Woo Kim
title	Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_short	Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_full	Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_fullStr	Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_full_unstemmed	Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells
title_sort	covalent, non-covalent, encapsulated nanodrug regulate the fate of intra- and extracellular trafficking: impact on cancer and normal cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9ec9053b99384ff5a15769de5c42b18f
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Covalent, Non-Covalent, Encapsulated Nanodrug Regulate the Fate of Intra- and Extracellular Trafficking: Impact on Cancer and Normal Cells

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