Biocatalytic trifluoromethylation of unprotected phenols

The introduction of fluorine into organic molecules often requires prefunctionalised molecules or protection of reactive functional groups. Here, the authors report a biocatalytic method for the trifluoromethylation of unprotected phenols under mild conditions.

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Detalles Bibliográficos
Autores principales: Robert C. Simon, Eduardo Busto, Nina Richter, Verena Resch, Kendall N. Houk, Wolfgang Kroutil
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/9ecbf7f3240549eeaf405aee97bb10fe
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Descripción
Sumario:The introduction of fluorine into organic molecules often requires prefunctionalised molecules or protection of reactive functional groups. Here, the authors report a biocatalytic method for the trifluoromethylation of unprotected phenols under mild conditions.