Pathogenicity and innate response to Avibacterium paragallinarum in chickens

ABSTRACT: Infectious coryza (IC) is an acute infectious upper respiratory disease in chickens. Recently, the prevalence of IC has increased in China. In this study, to clarify the pathogenic mechanism and innate immune response of Avibacterium paragallinarum (A. paragallinarum), an infection experim...

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Autores principales:	Mengjiao Guo, Donghui Liu, Xiufang Chen, Yantao Wu, Xiaorong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Avibacterium paragallinarum infectious coryza pathogenicity chicken innate immunity Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/9ed1e86c92a0484b92d99c541be9bbf8
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spelling	oai:doaj.org-article:9ed1e86c92a0484b92d99c541be9bbf82021-11-16T04:09:03ZPathogenicity and innate response to Avibacterium paragallinarum in chickens0032-579110.1016/j.psj.2021.101523https://doaj.org/article/9ed1e86c92a0484b92d99c541be9bbf82022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0032579121005459https://doaj.org/toc/0032-5791ABSTRACT: Infectious coryza (IC) is an acute infectious upper respiratory disease in chickens. Recently, the prevalence of IC has increased in China. In this study, to clarify the pathogenic mechanism and innate immune response of Avibacterium paragallinarum (A. paragallinarum), an infection experiment with A. paragallinarum was conducted. Our results showed that the whole course of IC was approximately 7 d. The clinical signs score was highest at 3 dpi and decreased from 5 dpi. A large amount of mucus and exudates was found in the infraorbital sinuses and nasal cavity. The A. paragallinarum contents in blood remained the highest, reaching 9.16 × 105 CFU/g at 5 dpi, which indicated that A. paragallinarum could rapidly invade the host, replicate in the blood and cause bacteremia. A. paragallinarum targets the upper respiratory tract. The infiltration of inflammatory cells, macrophages, and heterophilic granulocytes was only observed in the nasal cavity and infraorbital sinus. The Tlr4 and Nod1 pathways were activated and induced proinflammatory responses in chickens after infection with A. paragallinarum. The expression of Il1β and Il6 in the nasal cavity was significantly higher than that in the spleen, and it was consistent with the gross lesions and pathological changes. In particular, the expression of Il6 increased 229.07-fold at 1 dpi in the nasal cavity and increased 3.12-fold in the spleen. The high level of proinflammatory cytokines in the nasal cavity at an early stage of infection may be the main factor related to acute upper respiratory inflammation in chickens. These findings provide a reference for the occurrence and development of diseases mediated by A. paragallinarum.Mengjiao GuoDonghui LiuXiufang ChenYantao WuXiaorong ZhangElsevierarticleAvibacterium paragallinaruminfectious coryzapathogenicitychickeninnate immunityAnimal cultureSF1-1100ENPoultry Science, Vol 101, Iss 1, Pp 101523- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Avibacterium paragallinarum infectious coryza pathogenicity chicken innate immunity Animal culture SF1-1100
spellingShingle	Avibacterium paragallinarum infectious coryza pathogenicity chicken innate immunity Animal culture SF1-1100 Mengjiao Guo Donghui Liu Xiufang Chen Yantao Wu Xiaorong Zhang Pathogenicity and innate response to Avibacterium paragallinarum in chickens
description	ABSTRACT: Infectious coryza (IC) is an acute infectious upper respiratory disease in chickens. Recently, the prevalence of IC has increased in China. In this study, to clarify the pathogenic mechanism and innate immune response of Avibacterium paragallinarum (A. paragallinarum), an infection experiment with A. paragallinarum was conducted. Our results showed that the whole course of IC was approximately 7 d. The clinical signs score was highest at 3 dpi and decreased from 5 dpi. A large amount of mucus and exudates was found in the infraorbital sinuses and nasal cavity. The A. paragallinarum contents in blood remained the highest, reaching 9.16 × 105 CFU/g at 5 dpi, which indicated that A. paragallinarum could rapidly invade the host, replicate in the blood and cause bacteremia. A. paragallinarum targets the upper respiratory tract. The infiltration of inflammatory cells, macrophages, and heterophilic granulocytes was only observed in the nasal cavity and infraorbital sinus. The Tlr4 and Nod1 pathways were activated and induced proinflammatory responses in chickens after infection with A. paragallinarum. The expression of Il1β and Il6 in the nasal cavity was significantly higher than that in the spleen, and it was consistent with the gross lesions and pathological changes. In particular, the expression of Il6 increased 229.07-fold at 1 dpi in the nasal cavity and increased 3.12-fold in the spleen. The high level of proinflammatory cytokines in the nasal cavity at an early stage of infection may be the main factor related to acute upper respiratory inflammation in chickens. These findings provide a reference for the occurrence and development of diseases mediated by A. paragallinarum.
format	article
author	Mengjiao Guo Donghui Liu Xiufang Chen Yantao Wu Xiaorong Zhang
author_facet	Mengjiao Guo Donghui Liu Xiufang Chen Yantao Wu Xiaorong Zhang
author_sort	Mengjiao Guo
title	Pathogenicity and innate response to Avibacterium paragallinarum in chickens
title_short	Pathogenicity and innate response to Avibacterium paragallinarum in chickens
title_full	Pathogenicity and innate response to Avibacterium paragallinarum in chickens
title_fullStr	Pathogenicity and innate response to Avibacterium paragallinarum in chickens
title_full_unstemmed	Pathogenicity and innate response to Avibacterium paragallinarum in chickens
title_sort	pathogenicity and innate response to avibacterium paragallinarum in chickens
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/9ed1e86c92a0484b92d99c541be9bbf8
work_keys_str_mv	AT mengjiaoguo pathogenicityandinnateresponsetoavibacteriumparagallinaruminchickens AT donghuiliu pathogenicityandinnateresponsetoavibacteriumparagallinaruminchickens AT xiufangchen pathogenicityandinnateresponsetoavibacteriumparagallinaruminchickens AT yantaowu pathogenicityandinnateresponsetoavibacteriumparagallinaruminchickens AT xiaorongzhang pathogenicityandinnateresponsetoavibacteriumparagallinaruminchickens
_version_	1718426802821529600

Pathogenicity and innate response to Avibacterium paragallinarum in chickens

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