Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.

<h4>Background</h4>Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Soo Lim, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Young-Bum Kim, Kyong Soo Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ed3dad2145d432a847e76d3f92e677c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ed3dad2145d432a847e76d3f92e677c
record_format	dspace
spelling	oai:doaj.org-article:9ed3dad2145d432a847e76d3f92e677c2021-11-18T07:22:58ZEffect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.1932-620310.1371/journal.pone.0035007https://doaj.org/article/9ed3dad2145d432a847e76d3f92e677c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22493727/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms.<h4>Methods and findings</h4>Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs.<h4>Conclusions</h4>Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes.Soo LimSung Hee ChoiHayley ShinBong Jun ChoHo Seon ParkByung Yong AhnSeon Mee KangJi Won YoonHak Chul JangYoung-Bum KimKyong Soo ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35007 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soo Lim Sung Hee Choi Hayley Shin Bong Jun Cho Ho Seon Park Byung Yong Ahn Seon Mee Kang Ji Won Yoon Hak Chul Jang Young-Bum Kim Kyong Soo Park Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
description	<h4>Background</h4>Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms.<h4>Methods and findings</h4>Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs.<h4>Conclusions</h4>Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes.
format	article
author	Soo Lim Sung Hee Choi Hayley Shin Bong Jun Cho Ho Seon Park Byung Yong Ahn Seon Mee Kang Ji Won Yoon Hak Chul Jang Young-Bum Kim Kyong Soo Park
author_facet	Soo Lim Sung Hee Choi Hayley Shin Bong Jun Cho Ho Seon Park Byung Yong Ahn Seon Mee Kang Ji Won Yoon Hak Chul Jang Young-Bum Kim Kyong Soo Park
author_sort	Soo Lim
title	Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
title_short	Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
title_full	Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
title_fullStr	Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
title_full_unstemmed	Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
title_sort	effect of a dipeptidyl peptidase-iv inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9ed3dad2145d432a847e76d3f92e677c
work_keys_str_mv	AT soolim effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT sungheechoi effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT hayleyshin effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT bongjuncho effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT hoseonpark effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT byungyongahn effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT seonmeekang effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT jiwonyoon effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT hakchuljang effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT youngbumkim effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats AT kyongsoopark effectofadipeptidylpeptidaseivinhibitordesfluorositagliptinonneointimalformationafterballooninjuryinrats
_version_	1718423551190499328

Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats.

Ejemplares similares