Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry

The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. The Suzuki-Miyaura cross coupling is a fundamental C–C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way in which...

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Autores principales:	Daniele Cartagenova, Stephan Bachmann, Jereon A. van Bokhoven, Kurt Püntener, Marco Ranocchiari
Formato:	article
Lenguaje:	DE EN FR
Publicado:	Swiss Chemical Society 2021
Materias:	catalysis metal-organic framework pharma industry sustainable organic processes suzuki-miyaura cross coupling Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9ed6e13f80734bb0a04a34bb85b70eab
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spelling	oai:doaj.org-article:9ed6e13f80734bb0a04a34bb85b70eab2021-11-26T10:18:32ZHeterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry10.2533/chimia.2021.9720009-42932673-2424https://doaj.org/article/9ed6e13f80734bb0a04a34bb85b70eab2021-11-01T00:00:00Zhttps://doaj.org/toc/0009-4293https://doaj.org/toc/2673-2424The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. The Suzuki-Miyaura cross coupling is a fundamental C–C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way in which the synthesis of DS intermediates by C–C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal–organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki-Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide a complementary platform for reducing waste and the costs of production related to such transformations.Daniele CartagenovaStephan BachmannJereon A. van BokhovenKurt PüntenerMarco RanocchiariSwiss Chemical Societyarticlecatalysismetal-organic frameworkpharma industrysustainable organic processessuzuki-miyaura cross couplingChemistryQD1-999DEENFRCHIMIA, Vol 75, Iss 11, Pp 972-978 (2021)
institution	DOAJ
collection	DOAJ
language	DE EN FR
topic	catalysis metal-organic framework pharma industry sustainable organic processes suzuki-miyaura cross coupling Chemistry QD1-999
spellingShingle	catalysis metal-organic framework pharma industry sustainable organic processes suzuki-miyaura cross coupling Chemistry QD1-999 Daniele Cartagenova Stephan Bachmann Jereon A. van Bokhoven Kurt Püntener Marco Ranocchiari Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
description	The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. The Suzuki-Miyaura cross coupling is a fundamental C–C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way in which the synthesis of DS intermediates by C–C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal–organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki-Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide a complementary platform for reducing waste and the costs of production related to such transformations.
format	article
author	Daniele Cartagenova Stephan Bachmann Jereon A. van Bokhoven Kurt Püntener Marco Ranocchiari
author_facet	Daniele Cartagenova Stephan Bachmann Jereon A. van Bokhoven Kurt Püntener Marco Ranocchiari
author_sort	Daniele Cartagenova
title	Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
title_short	Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
title_full	Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
title_fullStr	Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
title_full_unstemmed	Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
title_sort	heterogeneous metal–organic framework catalysts for suzuki-miyaura cross coupling in the pharma industry
publisher	Swiss Chemical Society
publishDate	2021
url	https://doaj.org/article/9ed6e13f80734bb0a04a34bb85b70eab
work_keys_str_mv	AT danielecartagenova heterogeneousmetalorganicframeworkcatalystsforsuzukimiyauracrosscouplinginthepharmaindustry AT stephanbachmann heterogeneousmetalorganicframeworkcatalystsforsuzukimiyauracrosscouplinginthepharmaindustry AT jereonavanbokhoven heterogeneousmetalorganicframeworkcatalystsforsuzukimiyauracrosscouplinginthepharmaindustry AT kurtpuntener heterogeneousmetalorganicframeworkcatalystsforsuzukimiyauracrosscouplinginthepharmaindustry AT marcoranocchiari heterogeneousmetalorganicframeworkcatalystsforsuzukimiyauracrosscouplinginthepharmaindustry
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Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry

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