Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.

<h4>Background</h4>Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigat...

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Autores principales: Chih-Chien Wang, Chih-Yun Huang, Meng-Chang Lee, Dung-Jang Tsai, Chia-Chun Wu, Sui-Lung Su
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:9ee1d1cb222a4229b6eb3b41f43d67832021-12-02T20:04:17ZGenetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.1932-620310.1371/journal.pone.0259561https://doaj.org/article/9ee1d1cb222a4229b6eb3b41f43d67832021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259561https://doaj.org/toc/1932-6203<h4>Background</h4>Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained.<h4>Objective</h4>This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA.<h4>Methods</h4>Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren-Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue.<h4>Results</h4>A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62-1.15) in the recessive model] in the present case-control study, and analysis of other genetic models showed a similar trend. After adding the critical case-control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56-4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion.<h4>Conclusions</h4>The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.Chih-Chien WangChih-Yun HuangMeng-Chang LeeDung-Jang TsaiChia-Chun WuSui-Lung SuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259561 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Chih-Chien Wang
Chih-Yun Huang
Meng-Chang Lee
Dung-Jang Tsai
Chia-Chun Wu
Sui-Lung Su
Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
description <h4>Background</h4>Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained.<h4>Objective</h4>This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA.<h4>Methods</h4>Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren-Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue.<h4>Results</h4>A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62-1.15) in the recessive model] in the present case-control study, and analysis of other genetic models showed a similar trend. After adding the critical case-control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56-4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion.<h4>Conclusions</h4>The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.
format article
author Chih-Chien Wang
Chih-Yun Huang
Meng-Chang Lee
Dung-Jang Tsai
Chia-Chun Wu
Sui-Lung Su
author_facet Chih-Chien Wang
Chih-Yun Huang
Meng-Chang Lee
Dung-Jang Tsai
Chia-Chun Wu
Sui-Lung Su
author_sort Chih-Chien Wang
title Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
title_short Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
title_full Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
title_fullStr Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
title_full_unstemmed Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.
title_sort genetic association between tnf-α g-308a and osteoarthritis in asians: a case-control study and meta-analysis.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/9ee1d1cb222a4229b6eb3b41f43d6783
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