Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.

<h4>Background</h4>Parkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction.<h4>...

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Autores principales:	Petr Dušek, Robert Jech, Tomáš Sieger, Josef Vymazal, Evžen Růžička, Jiří Wackermann, Karsten Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ee3c752672a4e9e9a061a9e941764f0
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spelling	oai:doaj.org-article:9ee3c752672a4e9e9a061a9e941764f02021-11-18T07:30:47ZAbnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.1932-620310.1371/journal.pone.0029635https://doaj.org/article/9ee3c752672a4e9e9a061a9e941764f02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238630/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Parkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction.<h4>Methodology/findings</h4>The aim of the present study was to explore the neurophysiologic correlates of this deficit. We performed functional magnetic resonance imaging on twelve PD patients while they were performing a time reproduction task (TRT). The TRT consisted of an encoding phase (during which visual stimuli of durations from 5 s to 16.6 s, varied at 8 levels were presented) and a reproduction phase (during which interval durations were reproduced by a button pressing). Patients were scanned twice, once while on their DA medication (ON condition) and once after medication withdrawal (OFF condition). Differences in Blood-Oxygenation-Level-Dependent (BOLD) signal in ON and OFF conditions were evaluated. The time course of activation in the brain areas with different BOLD signal was plotted. There were no significant differences in the behavioral results, but a trend toward overestimation of intervals ≤11.9 s and underestimation of intervals ≥14.1 s in the OFF condition (p<0.088). During the reproduction phase, higher activation in the precuneus was found in the ON condition (p<0.05 corrected). Time course was plotted separately for long (≥14.1 s) and short (≤11.9 s) intervals. Results showed that there was a significant difference only in long intervals, when activity gradually decreased in the OFF, but remained stable in the ON condition. This difference in precuneus activation was not found during random button presses in a control task.<h4>Conclusions/significance</h4>Our results show that differences in precuneus activation during retrieval of a remembered duration may underlie some aspects of time perception deficit in PD patients. We suggest that DA medication may allow compensatory activation in the precuneus, which results in a more accurate retrieval of remembered interval duration.Petr DušekRobert JechTomáš SiegerJosef VymazalEvžen RůžičkaJiří WackermannKarsten MuellerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29635 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petr Dušek Robert Jech Tomáš Sieger Josef Vymazal Evžen Růžička Jiří Wackermann Karsten Mueller Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
description	<h4>Background</h4>Parkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction.<h4>Methodology/findings</h4>The aim of the present study was to explore the neurophysiologic correlates of this deficit. We performed functional magnetic resonance imaging on twelve PD patients while they were performing a time reproduction task (TRT). The TRT consisted of an encoding phase (during which visual stimuli of durations from 5 s to 16.6 s, varied at 8 levels were presented) and a reproduction phase (during which interval durations were reproduced by a button pressing). Patients were scanned twice, once while on their DA medication (ON condition) and once after medication withdrawal (OFF condition). Differences in Blood-Oxygenation-Level-Dependent (BOLD) signal in ON and OFF conditions were evaluated. The time course of activation in the brain areas with different BOLD signal was plotted. There were no significant differences in the behavioral results, but a trend toward overestimation of intervals ≤11.9 s and underestimation of intervals ≥14.1 s in the OFF condition (p<0.088). During the reproduction phase, higher activation in the precuneus was found in the ON condition (p<0.05 corrected). Time course was plotted separately for long (≥14.1 s) and short (≤11.9 s) intervals. Results showed that there was a significant difference only in long intervals, when activity gradually decreased in the OFF, but remained stable in the ON condition. This difference in precuneus activation was not found during random button presses in a control task.<h4>Conclusions/significance</h4>Our results show that differences in precuneus activation during retrieval of a remembered duration may underlie some aspects of time perception deficit in PD patients. We suggest that DA medication may allow compensatory activation in the precuneus, which results in a more accurate retrieval of remembered interval duration.
format	article
author	Petr Dušek Robert Jech Tomáš Sieger Josef Vymazal Evžen Růžička Jiří Wackermann Karsten Mueller
author_facet	Petr Dušek Robert Jech Tomáš Sieger Josef Vymazal Evžen Růžička Jiří Wackermann Karsten Mueller
author_sort	Petr Dušek
title	Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
title_short	Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
title_full	Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
title_fullStr	Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
title_full_unstemmed	Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
title_sort	abnormal activity in the precuneus during time perception in parkinson's disease: an fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9ee3c752672a4e9e9a061a9e941764f0
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Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.

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