Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals
Abstract Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific indispensable transcription factor Krueppel-like factor 1 (KLF1) is associated with high persistence of fetal hemoglobin (HPFH). The In(L...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9ee3cf0d7bf745ada041de96f847e1a5 |
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