Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder

Background: Attention deficit hyperactivity disorder (ADHD) is the most common developmental disorder in children. Studies suggest an association between fatty acids composition and ADHD pathogenesis. We aimed to investigate whether children diagnosed with ADHD present unique fatty acid profiles in...

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Autores principales:	Ayelet Armon-Omer, Eti Amir, Hadar Neuman, Saleh Khateeb, Itai Mizrachi, Monia Shalan, Snait Tamir, Uri Yatzkar
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ADHD trans-fatty acid CGI-S red blood cells DHA Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/9ee9312c05c045d892d4c0104afc18e1
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spelling	oai:doaj.org-article:9ee9312c05c045d892d4c0104afc18e12021-11-05T09:13:10ZUnique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder1664-064010.3389/fpsyt.2021.740169https://doaj.org/article/9ee9312c05c045d892d4c0104afc18e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.740169/fullhttps://doaj.org/toc/1664-0640Background: Attention deficit hyperactivity disorder (ADHD) is the most common developmental disorder in children. Studies suggest an association between fatty acids composition and ADHD pathogenesis. We aimed to investigate whether children diagnosed with ADHD present unique fatty acid profiles in red blood cells (RBC), as compared to children without ADHD.Method: We examined 60 children aged 6–14 years, out of which 32 were diagnosed with ADHD, and 28 were not. Blood was collected from all children to quantify an array of 26 fatty acids from RBC membranes. Fatty acid methyl esters were generated by acid transesterification and analyzed by gas chromatography.Results: We found that children with ADHD presented unique fatty acid profiles on RBC membranes with significantly higher levels of most of the trans-fatty acids (Total trans-fatty acids 0.64 ± 0.21 vs. 0.49 ± 0.18 p = 0.003) and lower levels of docosahexaenoic acid (DHA), as compared to controls (4.06 ± 0.79 vs. 4.68 ± 1.37 p = 0.040). Additionally, total trans-fatty acids were higher in children with extremely severe clinical ADHD condition score, as compared to milder ADHD scores and to control children (0.72 ± 0.18, 0.64 ± 0.20, 0.61 ± 0.22, 0.49 ± 0.18, p = 0.010, accordingly).Conclusion: Children with ADHD have higher levels of trans-fatty acids in RBCs, compared to children without ADHD. This study points to a possible link between trans-fatty acids and ADHD. Understanding these findings and the clinical meaning will potentially contribute to a more targeted dietary intervention.Ayelet Armon-OmerEti AmirHadar NeumanSaleh KhateebItai MizrachiMonia ShalanSnait TamirSnait TamirUri YatzkarUri YatzkarFrontiers Media S.A.articleADHDtrans-fatty acidCGI-Sred blood cellsDHAPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ADHD trans-fatty acid CGI-S red blood cells DHA Psychiatry RC435-571
spellingShingle	ADHD trans-fatty acid CGI-S red blood cells DHA Psychiatry RC435-571 Ayelet Armon-Omer Eti Amir Hadar Neuman Saleh Khateeb Itai Mizrachi Monia Shalan Snait Tamir Snait Tamir Uri Yatzkar Uri Yatzkar Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
description	Background: Attention deficit hyperactivity disorder (ADHD) is the most common developmental disorder in children. Studies suggest an association between fatty acids composition and ADHD pathogenesis. We aimed to investigate whether children diagnosed with ADHD present unique fatty acid profiles in red blood cells (RBC), as compared to children without ADHD.Method: We examined 60 children aged 6–14 years, out of which 32 were diagnosed with ADHD, and 28 were not. Blood was collected from all children to quantify an array of 26 fatty acids from RBC membranes. Fatty acid methyl esters were generated by acid transesterification and analyzed by gas chromatography.Results: We found that children with ADHD presented unique fatty acid profiles on RBC membranes with significantly higher levels of most of the trans-fatty acids (Total trans-fatty acids 0.64 ± 0.21 vs. 0.49 ± 0.18 p = 0.003) and lower levels of docosahexaenoic acid (DHA), as compared to controls (4.06 ± 0.79 vs. 4.68 ± 1.37 p = 0.040). Additionally, total trans-fatty acids were higher in children with extremely severe clinical ADHD condition score, as compared to milder ADHD scores and to control children (0.72 ± 0.18, 0.64 ± 0.20, 0.61 ± 0.22, 0.49 ± 0.18, p = 0.010, accordingly).Conclusion: Children with ADHD have higher levels of trans-fatty acids in RBCs, compared to children without ADHD. This study points to a possible link between trans-fatty acids and ADHD. Understanding these findings and the clinical meaning will potentially contribute to a more targeted dietary intervention.
format	article
author	Ayelet Armon-Omer Eti Amir Hadar Neuman Saleh Khateeb Itai Mizrachi Monia Shalan Snait Tamir Snait Tamir Uri Yatzkar Uri Yatzkar
author_facet	Ayelet Armon-Omer Eti Amir Hadar Neuman Saleh Khateeb Itai Mizrachi Monia Shalan Snait Tamir Snait Tamir Uri Yatzkar Uri Yatzkar
author_sort	Ayelet Armon-Omer
title	Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
title_short	Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
title_full	Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
title_fullStr	Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
title_full_unstemmed	Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder
title_sort	unique trans-fatty acid profile in children with attention deficit hyperactivity disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9ee9312c05c045d892d4c0104afc18e1
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Unique Trans-fatty Acid Profile in Children With Attention Deficit Hyperactivity Disorder

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