Acircularity and circularity indexes of the foveal avascular zone in high myopia

Abstract This study explored the association between foveal avascular zone (FAZ) parameters and high myopia using optical coherence tomography angiography. We divided 106 eyes of 106 patients into quartiles based on the axial length. The upper quartile was then defined as the high myopia group (n = ...

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Autores principales:	Helong Piao, Yue Guo, Haowei Zhang, Mi Sun Sung, Sang Woo Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9eec985075014c588a75edcec739f4ea
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spelling	oai:doaj.org-article:9eec985075014c588a75edcec739f4ea2021-12-02T15:10:39ZAcircularity and circularity indexes of the foveal avascular zone in high myopia10.1038/s41598-021-96304-92045-2322https://doaj.org/article/9eec985075014c588a75edcec739f4ea2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96304-9https://doaj.org/toc/2045-2322Abstract This study explored the association between foveal avascular zone (FAZ) parameters and high myopia using optical coherence tomography angiography. We divided 106 eyes of 106 patients into quartiles based on the axial length. The upper quartile was then defined as the high myopia group (n = 27), while the lower quartile was the non-high myopia group (n = 26). The areas and minor axis lengths of superficial and deep FAZ, the perimeters and major axis lengths of deep FAZ were significantly larger in eyes with high myopia than in eyes with non-high myopia (P < 0.05). Inversely, the subfoveal choroidal thickness was significantly thinner in eyes with high myopia than in those with non-high myopia. Linear regression analyses showed that no significant correlation was observed between FAZ areas and acircularity and circularity indexes of FAZ in non-high myopia group. Conversely, FAZ areas strongly correlated with acircularity and circularity indexes of FAZ in high myopia group. We found that an increase in the FAZ area in highly myopic eyes was accompanied by a significant variation in FAZ acircularity and circularity indexes. Further research should address whether these findings are associated with future disease development in highly myopic eyes.Helong PiaoYue GuoHaowei ZhangMi Sun SungSang Woo ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Helong Piao Yue Guo Haowei Zhang Mi Sun Sung Sang Woo Park Acircularity and circularity indexes of the foveal avascular zone in high myopia
description	Abstract This study explored the association between foveal avascular zone (FAZ) parameters and high myopia using optical coherence tomography angiography. We divided 106 eyes of 106 patients into quartiles based on the axial length. The upper quartile was then defined as the high myopia group (n = 27), while the lower quartile was the non-high myopia group (n = 26). The areas and minor axis lengths of superficial and deep FAZ, the perimeters and major axis lengths of deep FAZ were significantly larger in eyes with high myopia than in eyes with non-high myopia (P < 0.05). Inversely, the subfoveal choroidal thickness was significantly thinner in eyes with high myopia than in those with non-high myopia. Linear regression analyses showed that no significant correlation was observed between FAZ areas and acircularity and circularity indexes of FAZ in non-high myopia group. Conversely, FAZ areas strongly correlated with acircularity and circularity indexes of FAZ in high myopia group. We found that an increase in the FAZ area in highly myopic eyes was accompanied by a significant variation in FAZ acircularity and circularity indexes. Further research should address whether these findings are associated with future disease development in highly myopic eyes.
format	article
author	Helong Piao Yue Guo Haowei Zhang Mi Sun Sung Sang Woo Park
author_facet	Helong Piao Yue Guo Haowei Zhang Mi Sun Sung Sang Woo Park
author_sort	Helong Piao
title	Acircularity and circularity indexes of the foveal avascular zone in high myopia
title_short	Acircularity and circularity indexes of the foveal avascular zone in high myopia
title_full	Acircularity and circularity indexes of the foveal avascular zone in high myopia
title_fullStr	Acircularity and circularity indexes of the foveal avascular zone in high myopia
title_full_unstemmed	Acircularity and circularity indexes of the foveal avascular zone in high myopia
title_sort	acircularity and circularity indexes of the foveal avascular zone in high myopia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9eec985075014c588a75edcec739f4ea
work_keys_str_mv	AT helongpiao acircularityandcircularityindexesofthefovealavascularzoneinhighmyopia AT yueguo acircularityandcircularityindexesofthefovealavascularzoneinhighmyopia AT haoweizhang acircularityandcircularityindexesofthefovealavascularzoneinhighmyopia AT misunsung acircularityandcircularityindexesofthefovealavascularzoneinhighmyopia AT sangwoopark acircularityandcircularityindexesofthefovealavascularzoneinhighmyopia
_version_	1718387708367208448

Acircularity and circularity indexes of the foveal avascular zone in high myopia

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