Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats

Objective: Animal experiments have demonstrated that selenium can partly reduce nephrotoxicity and neurotoxicity of lead. There is no study about possible interactions between lead and selenium in functioning of salivary glands. This study was designed to explore the possible protective effects of s...

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Autores principales:	M Abdollahi, N Rahmat Girdeh, M Marzban
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2000
Materias:	lead selenium salivary gland rat saliva Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9eecae8d751841b39689b48c7857c127
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spelling	oai:doaj.org-article:9eecae8d751841b39689b48c7857c1272021-11-10T09:22:07ZProtective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats1561-41072251-7170https://doaj.org/article/9eecae8d751841b39689b48c7857c1272000-04-01T00:00:00Zhttp://jbums.org/article-1-2906-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Animal experiments have demonstrated that selenium can partly reduce nephrotoxicity and neurotoxicity of lead. There is no study about possible interactions between lead and selenium in functioning of salivary glands. This study was designed to explore the possible protective effects of selenium on lead-induced alterations on rat submandibular gland function. Methods: Pure submandibular saliva was collected intraorally by micro polyethylene cannula from anaesthetized rats using pilocarpine as secretagogue. Findings: A twenty-four day treatment with lead 0.04% and 0.05% as acetate in drinking water altered salivary function. Flow rate was significantly increased by lead (0.04% and 0.05%, P<0.01). The total protein and calcium concentrations of saliva were decreased significantly by either doses of lead (P<0.01). Also both doses of lead decreased the activity of NAG significantly (P<0.01). Selenium alone treatment (2.5 mg/L) in drinking water for 24 days did not induce any significant change in saliva secretory function but treatment with lead and selenium compensated the lead-induced decrease in NAG activity and concentrations of calcium and protein significantly at P<0.01 and raised them to levels close to those in controls. Increased flow rate by lead acetate was also affected by selenium co-treatment and reached that level in control. Conclusion: It is concluded that selenium can prevent lead-induced adverse effects on rat submandibular gland function. Properties of selenium as antioxidative, free radical scavenger and maintenance of cell membrane integrity are possible mechanisms of its protective effects. Further studies about interaction of lead and selenium in salivary glands at molecular level are proposed to explore the exact mechanism of their interaction.M AbdollahiN Rahmat GirdehM MarzbanBabol University of Medical Sciencesarticleleadseleniumsalivary glandratsalivaMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 2, Pp 8-15 (2000)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	lead selenium salivary gland rat saliva Medicine R Medicine (General) R5-920
spellingShingle	lead selenium salivary gland rat saliva Medicine R Medicine (General) R5-920 M Abdollahi N Rahmat Girdeh M Marzban Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
description	Objective: Animal experiments have demonstrated that selenium can partly reduce nephrotoxicity and neurotoxicity of lead. There is no study about possible interactions between lead and selenium in functioning of salivary glands. This study was designed to explore the possible protective effects of selenium on lead-induced alterations on rat submandibular gland function. Methods: Pure submandibular saliva was collected intraorally by micro polyethylene cannula from anaesthetized rats using pilocarpine as secretagogue. Findings: A twenty-four day treatment with lead 0.04% and 0.05% as acetate in drinking water altered salivary function. Flow rate was significantly increased by lead (0.04% and 0.05%, P<0.01). The total protein and calcium concentrations of saliva were decreased significantly by either doses of lead (P<0.01). Also both doses of lead decreased the activity of NAG significantly (P<0.01). Selenium alone treatment (2.5 mg/L) in drinking water for 24 days did not induce any significant change in saliva secretory function but treatment with lead and selenium compensated the lead-induced decrease in NAG activity and concentrations of calcium and protein significantly at P<0.01 and raised them to levels close to those in controls. Increased flow rate by lead acetate was also affected by selenium co-treatment and reached that level in control. Conclusion: It is concluded that selenium can prevent lead-induced adverse effects on rat submandibular gland function. Properties of selenium as antioxidative, free radical scavenger and maintenance of cell membrane integrity are possible mechanisms of its protective effects. Further studies about interaction of lead and selenium in salivary glands at molecular level are proposed to explore the exact mechanism of their interaction.
format	article
author	M Abdollahi N Rahmat Girdeh M Marzban
author_facet	M Abdollahi N Rahmat Girdeh M Marzban
author_sort	M Abdollahi
title	Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
title_short	Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
title_full	Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
title_fullStr	Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
title_full_unstemmed	Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats
title_sort	protective effects of selenium on lead impacts in functioning of submandibular salivary gland of rats
publisher	Babol University of Medical Sciences
publishDate	2000
url	https://doaj.org/article/9eecae8d751841b39689b48c7857c127
work_keys_str_mv	AT mabdollahi protectiveeffectsofseleniumonleadimpactsinfunctioningofsubmandibularsalivaryglandofrats AT nrahmatgirdeh protectiveeffectsofseleniumonleadimpactsinfunctioningofsubmandibularsalivaryglandofrats AT mmarzban protectiveeffectsofseleniumonleadimpactsinfunctioningofsubmandibularsalivaryglandofrats
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Protective effects of Selenium on Lead impacts in functioning of submandibular salivary gland of rats

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