First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia

CD28 null T helper (Th) cells are rare in healthy individuals, but they are increased in various inflammatory and immune-mediated diseases. In this study, we determined the size of the CD4+/CD28 null T lymphocyte compartment in the peripheral blood of 40 autoimmune hemolytic anemia (AIHA) patients (...

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Autores principales:	Soha R. Youssef, Walaa A. Elsalakawy
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Flow cytometry CD4+/CD28 null T lymphocyte Autoimmune hemolytic anemia Th cells T lymphocytes CD4 helper T cells Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/9eef52f3b6224a3584bff666cd1923ad
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spelling	oai:doaj.org-article:9eef52f3b6224a3584bff666cd1923ad2021-11-04T04:36:52ZFirst report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia2531-137910.1016/j.htct.2020.04.010https://doaj.org/article/9eef52f3b6224a3584bff666cd1923ad2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137920300821https://doaj.org/toc/2531-1379CD28 null T helper (Th) cells are rare in healthy individuals, but they are increased in various inflammatory and immune-mediated diseases. In this study, we determined the size of the CD4+/CD28 null T lymphocyte compartment in the peripheral blood of 40 autoimmune hemolytic anemia (AIHA) patients (idiopathic and secondary) and 20 healthy control subjects, using tri-color flow cytometry. The frequency and absolute count of CD4+/CD28 null T helper (Th) cells was significantly higher in idiopathic AIHA patients, compared to healthy controls (p = 0.001 and 0.001, respectively) and to patients with secondary AIHA (p = 0.04 and 0.01, respectively). The percentage of CD4+/CD28 null Th cells was also negatively correlated to the hemoglobin (Hb) level (p = 0.03). These findings demonstrate, for the first time, the expansion of this phenotypically-defined population of T lymphocytes in patients with idiopathic AIHA and indicate that it likely plays an etiological role in the development of this disease. However, establishing the use of this marker for diagnosis or monitoring treatment of such patients needs further studies.Soha R. YoussefWalaa A. ElsalakawyElsevierarticleFlow cytometryCD4+/CD28 null T lymphocyteAutoimmune hemolytic anemiaTh cellsT lymphocytesCD4 helper T cellsDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 396-401 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Flow cytometry CD4+/CD28 null T lymphocyte Autoimmune hemolytic anemia Th cells T lymphocytes CD4 helper T cells Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Flow cytometry CD4+/CD28 null T lymphocyte Autoimmune hemolytic anemia Th cells T lymphocytes CD4 helper T cells Diseases of the blood and blood-forming organs RC633-647.5 Soha R. Youssef Walaa A. Elsalakawy First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
description	CD28 null T helper (Th) cells are rare in healthy individuals, but they are increased in various inflammatory and immune-mediated diseases. In this study, we determined the size of the CD4+/CD28 null T lymphocyte compartment in the peripheral blood of 40 autoimmune hemolytic anemia (AIHA) patients (idiopathic and secondary) and 20 healthy control subjects, using tri-color flow cytometry. The frequency and absolute count of CD4+/CD28 null T helper (Th) cells was significantly higher in idiopathic AIHA patients, compared to healthy controls (p = 0.001 and 0.001, respectively) and to patients with secondary AIHA (p = 0.04 and 0.01, respectively). The percentage of CD4+/CD28 null Th cells was also negatively correlated to the hemoglobin (Hb) level (p = 0.03). These findings demonstrate, for the first time, the expansion of this phenotypically-defined population of T lymphocytes in patients with idiopathic AIHA and indicate that it likely plays an etiological role in the development of this disease. However, establishing the use of this marker for diagnosis or monitoring treatment of such patients needs further studies.
format	article
author	Soha R. Youssef Walaa A. Elsalakawy
author_facet	Soha R. Youssef Walaa A. Elsalakawy
author_sort	Soha R. Youssef
title	First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
title_short	First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
title_full	First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
title_fullStr	First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
title_full_unstemmed	First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
title_sort	first report of expansion of cd4+/cd28 null t-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9eef52f3b6224a3584bff666cd1923ad
work_keys_str_mv	AT soharyoussef firstreportofexpansionofcd4cd28nullthelperlymphocytesinadultpatientswithidiopathicautoimmunehemolyticanemia AT walaaaelsalakawy firstreportofexpansionofcd4cd28nullthelperlymphocytesinadultpatientswithidiopathicautoimmunehemolyticanemia
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First report of expansion of CD4+/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia

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