Integrative discovery of treatments for high-risk neuroblastoma

We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and identify and validate promising drug targets.

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Detalles Bibliográficos
Autores principales:	Elin Almstedt, Ramy Elgendy, Neda Hekmati, Emil Rosén, Caroline Wärn, Thale Kristin Olsen, Cecilia Dyberg, Milena Doroszko, Ida Larsson, Anders Sundström, Marie Arsenian Henriksson, Sven Påhlman, Daniel Bexell, Michael Vanlandewijck, Per Kogner, Rebecka Jörnsten, Cecilia Krona, Sven Nelander
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:9eefbf3ff5bb4e6b9e9c8aacbd9a935c2021-12-02T14:40:42ZIntegrative discovery of treatments for high-risk neuroblastoma10.1038/s41467-019-13817-82041-1723https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13817-8https://doaj.org/toc/2041-1723We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and identify and validate promising drug targets.Elin AlmstedtRamy ElgendyNeda HekmatiEmil RosénCaroline WärnThale Kristin OlsenCecilia DybergMilena DoroszkoIda LarssonAnders SundströmMarie Arsenian HenrikssonSven PåhlmanDaniel BexellMichael VanlandewijckPer KognerRebecka JörnstenCecilia KronaSven NelanderNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elin Almstedt Ramy Elgendy Neda Hekmati Emil Rosén Caroline Wärn Thale Kristin Olsen Cecilia Dyberg Milena Doroszko Ida Larsson Anders Sundström Marie Arsenian Henriksson Sven Påhlman Daniel Bexell Michael Vanlandewijck Per Kogner Rebecka Jörnsten Cecilia Krona Sven Nelander Integrative discovery of treatments for high-risk neuroblastoma
description	We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and identify and validate promising drug targets.
format	article
author	Elin Almstedt Ramy Elgendy Neda Hekmati Emil Rosén Caroline Wärn Thale Kristin Olsen Cecilia Dyberg Milena Doroszko Ida Larsson Anders Sundström Marie Arsenian Henriksson Sven Påhlman Daniel Bexell Michael Vanlandewijck Per Kogner Rebecka Jörnsten Cecilia Krona Sven Nelander
author_facet	Elin Almstedt Ramy Elgendy Neda Hekmati Emil Rosén Caroline Wärn Thale Kristin Olsen Cecilia Dyberg Milena Doroszko Ida Larsson Anders Sundström Marie Arsenian Henriksson Sven Påhlman Daniel Bexell Michael Vanlandewijck Per Kogner Rebecka Jörnsten Cecilia Krona Sven Nelander
author_sort	Elin Almstedt
title	Integrative discovery of treatments for high-risk neuroblastoma
title_short	Integrative discovery of treatments for high-risk neuroblastoma
title_full	Integrative discovery of treatments for high-risk neuroblastoma
title_fullStr	Integrative discovery of treatments for high-risk neuroblastoma
title_full_unstemmed	Integrative discovery of treatments for high-risk neuroblastoma
title_sort	integrative discovery of treatments for high-risk neuroblastoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c
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Integrative discovery of treatments for high-risk neuroblastoma

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