Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions

<i>Background and Objectives:</i> We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), noninvasiv...

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Autores principales:	Hao-Wen Chuang, Jyh-Seng Wang, Jen-Wei Tsai, Chao-Tien Hsu, Kai-Jen Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	immunohistochemistry <i>BRAF</i><sup>V600E</sup> NIFTP encapsulated follicular variant papillary thyroid carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9ef106203c2f4e299973c5c7f0267b6c
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spelling	oai:doaj.org-article:9ef106203c2f4e299973c5c7f0267b6c2021-11-25T18:18:55ZImmunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions10.3390/medicina571112461648-91441010-660Xhttps://doaj.org/article/9ef106203c2f4e299973c5c7f0267b6c2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1246https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives:</i> We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), noninvasive encapsulated follicular variants of papillary thyroid carcinoma (NEFVPTCs), and infiltrative FVPTC (IFVPTC). <i>Materials and Methods:</i> Sixty-three cases were classified as BFNs, NIFTPs, NEFVPTCs, or IFVPTCs and were evaluated using the following markers: CK19, CD56, galectin-3, CITED1, HBME-1, VE1, and TROP-2. <i>Results:</i> The IHC results for NIFTP and NEFVPTC exhibited no statistically significant differences. In differentiating IFVPTCs from BFNs and NIFTPs/NEFVPTCs, galectin-3 and TROP-2 were the markers with the highest sensitivity plus high specificity, respectively. In various combinations, panel co-expression of two markers, including galectin-3 and/or HBME-1 and/or TROP-2, and the combination of galectin-3 and TROP-2 co-expression could achieve 100% in all aspects. In terms of discrimination of BFNs from NIFTP/NEFVPTC, CK19 was the single most sensitive marker (81.3%), while CD56 was the most specific (100%). The panel consisting of CK19 and/or HBME-1 exhibited the greatest sensitivity (96.9%), but the panel with CD56 and/or HBME-1 exhibited the greatest specificity (90.5%). <i>Conclusions:</i> Our results broaden the use of IHC markers for differential diagnoses among the four groups of follicular-based lesions. In addition, the similar IHC profiles of NIFTP and NEFVPTC also suggest the original criterion of <1% papillae within tumors, providing a reliable NIFTP diagnosis. Their close relationship may represent a spectrum of progressing neoplasia.Hao-Wen ChuangJyh-Seng WangJen-Wei TsaiChao-Tien HsuKai-Jen LinMDPI AGarticleimmunohistochemistry<i>BRAF</i><sup>V600E</sup>NIFTPencapsulatedfollicular variantpapillary thyroid carcinomaMedicine (General)R5-920ENMedicina, Vol 57, Iss 1246, p 1246 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunohistochemistry <i>BRAF</i><sup>V600E</sup> NIFTP encapsulated follicular variant papillary thyroid carcinoma Medicine (General) R5-920
spellingShingle	immunohistochemistry <i>BRAF</i><sup>V600E</sup> NIFTP encapsulated follicular variant papillary thyroid carcinoma Medicine (General) R5-920 Hao-Wen Chuang Jyh-Seng Wang Jen-Wei Tsai Chao-Tien Hsu Kai-Jen Lin Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
description	<i>Background and Objectives:</i> We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), noninvasive encapsulated follicular variants of papillary thyroid carcinoma (NEFVPTCs), and infiltrative FVPTC (IFVPTC). <i>Materials and Methods:</i> Sixty-three cases were classified as BFNs, NIFTPs, NEFVPTCs, or IFVPTCs and were evaluated using the following markers: CK19, CD56, galectin-3, CITED1, HBME-1, VE1, and TROP-2. <i>Results:</i> The IHC results for NIFTP and NEFVPTC exhibited no statistically significant differences. In differentiating IFVPTCs from BFNs and NIFTPs/NEFVPTCs, galectin-3 and TROP-2 were the markers with the highest sensitivity plus high specificity, respectively. In various combinations, panel co-expression of two markers, including galectin-3 and/or HBME-1 and/or TROP-2, and the combination of galectin-3 and TROP-2 co-expression could achieve 100% in all aspects. In terms of discrimination of BFNs from NIFTP/NEFVPTC, CK19 was the single most sensitive marker (81.3%), while CD56 was the most specific (100%). The panel consisting of CK19 and/or HBME-1 exhibited the greatest sensitivity (96.9%), but the panel with CD56 and/or HBME-1 exhibited the greatest specificity (90.5%). <i>Conclusions:</i> Our results broaden the use of IHC markers for differential diagnoses among the four groups of follicular-based lesions. In addition, the similar IHC profiles of NIFTP and NEFVPTC also suggest the original criterion of <1% papillae within tumors, providing a reliable NIFTP diagnosis. Their close relationship may represent a spectrum of progressing neoplasia.
format	article
author	Hao-Wen Chuang Jyh-Seng Wang Jen-Wei Tsai Chao-Tien Hsu Kai-Jen Lin
author_facet	Hao-Wen Chuang Jyh-Seng Wang Jen-Wei Tsai Chao-Tien Hsu Kai-Jen Lin
author_sort	Hao-Wen Chuang
title	Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
title_short	Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
title_full	Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
title_fullStr	Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
title_full_unstemmed	Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions
title_sort	immunohistochemistry helps to distinguish noninvasive follicular thyroid neoplasm with papillary-like nuclear features/noninvasive encapsulated follicular variant of papillary thyroid carcinoma with other follicular thyroid lesions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ef106203c2f4e299973c5c7f0267b6c
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Immunohistochemistry Helps to Distinguish Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features/Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Other Follicular Thyroid Lesions

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