Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction

Background and Aims: Vitamin D counteracts the reduction in the peripheral conversion of tiroxine (T4) into triiodothyronine (T3), which is the mechanism of low T3 syndrome (LT3) in acute myocardial infarction (AMI). The aim of this study was to assess the relationship between LT3 and hypovitaminosi...

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Autores principales:	Alessandro Pingitore, Francesca Mastorci, Sergio Berti, Laura Sabatino, Cataldo Palmieri, Giorgio Iervasi, Cristina Vassalle
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute myocardial infarction low T3 syndrome hypovitaminosis D Medicine R
Acceso en línea:	https://doaj.org/article/9ef15f02c3684ef3a2e6ebeb548c830e
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spelling	oai:doaj.org-article:9ef15f02c3684ef3a2e6ebeb548c830e2021-11-25T18:01:08ZHypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction10.3390/jcm102252672077-0383https://doaj.org/article/9ef15f02c3684ef3a2e6ebeb548c830e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5267https://doaj.org/toc/2077-0383Background and Aims: Vitamin D counteracts the reduction in the peripheral conversion of tiroxine (T4) into triiodothyronine (T3), which is the mechanism of low T3 syndrome (LT3) in acute myocardial infarction (AMI). The aim of this study was to assess the relationship between LT3 and hypovitaminosis D in AMI patients. Methods and Results: One hundred and twenty-four AMI patients were enrolled. Blood samples were taken at admission, and at 3, 12, 24, 48, and 72 h after admission. LT3 was defined as a value of fT3 ≤ 2.2 pg/mL, occurring within 3 days of hospital admission. Levels were defined as follows: sufficiency as a value of ±30 ng/mL, vitamin D insufficiency as 25-hydroxyvitamin D (25(OH)D) between 21 and 29 ng/mL, deficiency in 25(OH)D as below 20 ng/mL, and severe deficiency as values under 10 ng/mL. The percentage of subjects with severe 25(OH)D deficiency was significantly higher in the LT3 group (33% vs. 13%, <i>p</i> < 0.01). When LT3S was evaluated as a dependent variable, severe 25(OH)D deficiency (OR 2.6: 95%CI 1–6.7, <i>p</i> < 0.05) remained as an independent determinant after logistic multivariate adjustment together with age (>69 yrs, 50th percentile; OR 3.4, 95% CI 1.3–8.3, <i>p</i> < 0.01), but not female gender (OR 1.7, 95% CI 0.7–4.2, <i>p</i> = ns). Conclusions: This pilot study shows a relationship between hypovitaminosis D and LT3 in AMI patients. This association opens potential therapeutic challenges concerning the restoration of euthyroidism through vitamin D administration, together with the normalization of hypovitaminosis.Alessandro PingitoreFrancesca MastorciSergio BertiLaura SabatinoCataldo PalmieriGiorgio IervasiCristina VassalleMDPI AGarticleacute myocardial infarctionlow T3 syndromehypovitaminosis DMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5267, p 5267 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute myocardial infarction low T3 syndrome hypovitaminosis D Medicine R
spellingShingle	acute myocardial infarction low T3 syndrome hypovitaminosis D Medicine R Alessandro Pingitore Francesca Mastorci Sergio Berti Laura Sabatino Cataldo Palmieri Giorgio Iervasi Cristina Vassalle Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
description	Background and Aims: Vitamin D counteracts the reduction in the peripheral conversion of tiroxine (T4) into triiodothyronine (T3), which is the mechanism of low T3 syndrome (LT3) in acute myocardial infarction (AMI). The aim of this study was to assess the relationship between LT3 and hypovitaminosis D in AMI patients. Methods and Results: One hundred and twenty-four AMI patients were enrolled. Blood samples were taken at admission, and at 3, 12, 24, 48, and 72 h after admission. LT3 was defined as a value of fT3 ≤ 2.2 pg/mL, occurring within 3 days of hospital admission. Levels were defined as follows: sufficiency as a value of ±30 ng/mL, vitamin D insufficiency as 25-hydroxyvitamin D (25(OH)D) between 21 and 29 ng/mL, deficiency in 25(OH)D as below 20 ng/mL, and severe deficiency as values under 10 ng/mL. The percentage of subjects with severe 25(OH)D deficiency was significantly higher in the LT3 group (33% vs. 13%, <i>p</i> < 0.01). When LT3S was evaluated as a dependent variable, severe 25(OH)D deficiency (OR 2.6: 95%CI 1–6.7, <i>p</i> < 0.05) remained as an independent determinant after logistic multivariate adjustment together with age (>69 yrs, 50th percentile; OR 3.4, 95% CI 1.3–8.3, <i>p</i> < 0.01), but not female gender (OR 1.7, 95% CI 0.7–4.2, <i>p</i> = ns). Conclusions: This pilot study shows a relationship between hypovitaminosis D and LT3 in AMI patients. This association opens potential therapeutic challenges concerning the restoration of euthyroidism through vitamin D administration, together with the normalization of hypovitaminosis.
format	article
author	Alessandro Pingitore Francesca Mastorci Sergio Berti Laura Sabatino Cataldo Palmieri Giorgio Iervasi Cristina Vassalle
author_facet	Alessandro Pingitore Francesca Mastorci Sergio Berti Laura Sabatino Cataldo Palmieri Giorgio Iervasi Cristina Vassalle
author_sort	Alessandro Pingitore
title	Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
title_short	Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
title_full	Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
title_fullStr	Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
title_full_unstemmed	Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction
title_sort	hypovitaminosis d and low t3 syndrome: a link for therapeutic challenges in patients with acute myocardial infarction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9ef15f02c3684ef3a2e6ebeb548c830e
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Hypovitaminosis D and Low T3 Syndrome: A Link for Therapeutic Challenges in Patients with Acute Myocardial Infarction

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