Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study

Yuliya O Knyahnytska,1,2 Daniel M Blumberger,1–3 Zafiris J Daskalakis,1,2 Reza Zomorrodi,1 Allan S Kaplan1,2  1Temerty Centre for Therapeutic- Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 2Department of Psychiatry, University of Toronto, To...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Knyahnytska YO, Blumberger DM, Daskalakis ZJ, Zomorrodi R, Kaplan AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	severe and enduring anorexia nervosa deep transcranial magnetic stimulation repetitive transcranial magnetic stimulation insula Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9ef7554eca4d415e9c1d7961442e792d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ef7554eca4d415e9c1d7961442e792d
record_format	dspace
spelling	oai:doaj.org-article:9ef7554eca4d415e9c1d7961442e792d2021-12-02T05:18:13ZInsula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study1178-2021https://doaj.org/article/9ef7554eca4d415e9c1d7961442e792d2019-08-01T00:00:00Zhttps://www.dovepress.com/insula-h-coil-deep-transcranial-magnetic-stimulation-in-severe-and-end-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yuliya O Knyahnytska,1,2 Daniel M Blumberger,1–3 Zafiris J Daskalakis,1,2 Reza Zomorrodi,1 Allan S Kaplan1,2  1Temerty Centre for Therapeutic- Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 2Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 3Geriatric Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaIntroduction: Anorexia nervosa (AN) is a complex disorder of unknown etiology, characterized by obsessions and compulsions around body shape, weight, and calorie intake. In the course of AN, 10%–30% will recover, while the rest will develop a treatment-resistant course with a high mortality rate due to AN-related complications. The insula is a region in the brain of considerable interest to its role in gustatory modulation, feeding behavior, and processing of interoceptive stimuli.Objective: Recent advances in the neurophysiology of AN suggest insula dysfunction as a potential biomarker for people with severe and enduring AN (SE-AN). Deep transcranial magnetic stimulation (dTMS) is of particular interest in SE-AN because of its ability to target deep areas of the brain.Design: We conducted a pilot study to investigate the feasibility and safety of insula dTMS in subjects with SE-AN.Results: We found that dTMS is a safe and well-tolerated treatment. We also found a reduction in AN-related obsessions and compulsions, as well as depression and anxiety scores from baseline to the end of the trial. Due to small sample size, the results of this study should be interpreted with great caution.Discussion: The results suggest that dTMS is safe and well tolerated and may be of some clinical interest in patients with SE-AN. However, to determine the true efficacy of dTMS for SE-AN, there is a need to conduct a randomized controlled trial comparing real versus sham dTMS in a larger number of AN subjects.Keywords: severe and enduring anorexia nervosa, deep transcranial magnetic stimulation, repetitive transcranial magnetic stimulation, insulaKnyahnytska YOBlumberger DMDaskalakis ZJZomorrodi RKaplan ASDove Medical Pressarticlesevere and enduring anorexia nervosadeep transcranial magnetic stimulationrepetitive transcranial magnetic stimulationinsulaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2247-2256 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	severe and enduring anorexia nervosa deep transcranial magnetic stimulation repetitive transcranial magnetic stimulation insula Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	severe and enduring anorexia nervosa deep transcranial magnetic stimulation repetitive transcranial magnetic stimulation insula Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Knyahnytska YO Blumberger DM Daskalakis ZJ Zomorrodi R Kaplan AS Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
description	Yuliya O Knyahnytska,1,2 Daniel M Blumberger,1–3 Zafiris J Daskalakis,1,2 Reza Zomorrodi,1 Allan S Kaplan1,2  1Temerty Centre for Therapeutic- Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 2Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; 3Geriatric Division, Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaIntroduction: Anorexia nervosa (AN) is a complex disorder of unknown etiology, characterized by obsessions and compulsions around body shape, weight, and calorie intake. In the course of AN, 10%–30% will recover, while the rest will develop a treatment-resistant course with a high mortality rate due to AN-related complications. The insula is a region in the brain of considerable interest to its role in gustatory modulation, feeding behavior, and processing of interoceptive stimuli.Objective: Recent advances in the neurophysiology of AN suggest insula dysfunction as a potential biomarker for people with severe and enduring AN (SE-AN). Deep transcranial magnetic stimulation (dTMS) is of particular interest in SE-AN because of its ability to target deep areas of the brain.Design: We conducted a pilot study to investigate the feasibility and safety of insula dTMS in subjects with SE-AN.Results: We found that dTMS is a safe and well-tolerated treatment. We also found a reduction in AN-related obsessions and compulsions, as well as depression and anxiety scores from baseline to the end of the trial. Due to small sample size, the results of this study should be interpreted with great caution.Discussion: The results suggest that dTMS is safe and well tolerated and may be of some clinical interest in patients with SE-AN. However, to determine the true efficacy of dTMS for SE-AN, there is a need to conduct a randomized controlled trial comparing real versus sham dTMS in a larger number of AN subjects.Keywords: severe and enduring anorexia nervosa, deep transcranial magnetic stimulation, repetitive transcranial magnetic stimulation, insula
format	article
author	Knyahnytska YO Blumberger DM Daskalakis ZJ Zomorrodi R Kaplan AS
author_facet	Knyahnytska YO Blumberger DM Daskalakis ZJ Zomorrodi R Kaplan AS
author_sort	Knyahnytska YO
title	Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
title_short	Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
title_full	Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
title_fullStr	Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
title_full_unstemmed	Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study
title_sort	insula h-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (se-an): a pilot study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9ef7554eca4d415e9c1d7961442e792d
work_keys_str_mv	AT knyahnytskayo insulahcoildeeptranscranialmagneticstimulationinsevereandenduringanorexianervosaseanapilotstudy AT blumbergerdm insulahcoildeeptranscranialmagneticstimulationinsevereandenduringanorexianervosaseanapilotstudy AT daskalakiszj insulahcoildeeptranscranialmagneticstimulationinsevereandenduringanorexianervosaseanapilotstudy AT zomorrodir insulahcoildeeptranscranialmagneticstimulationinsevereandenduringanorexianervosaseanapilotstudy AT kaplanas insulahcoildeeptranscranialmagneticstimulationinsevereandenduringanorexianervosaseanapilotstudy
_version_	1718400486549225472

Insula H-coil deep transcranial magnetic stimulation in severe and enduring anorexia nervosa (SE-AN): a pilot study

Ejemplares similares