Production of unstable proteins through the formation of stable core complexes

Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quantities sufficient for structural and functional stu...

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Autores principales:	Nicolas Levy, Sylvia Eiler, Karine Pradeau-Aubreton, Benoit Maillot, François Stricher, Marc Ruff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ef95dc3bce44f668e21a106a000cf31
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spelling	oai:doaj.org-article:9ef95dc3bce44f668e21a106a000cf312021-12-02T17:32:22ZProduction of unstable proteins through the formation of stable core complexes10.1038/ncomms109322041-1723https://doaj.org/article/9ef95dc3bce44f668e21a106a000cf312016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10932https://doaj.org/toc/2041-1723Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quantities sufficient for structural and functional studies.Nicolas LevySylvia EilerKarine Pradeau-AubretonBenoit MaillotFrançois StricherMarc RuffNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Levy Sylvia Eiler Karine Pradeau-Aubreton Benoit Maillot François Stricher Marc Ruff Production of unstable proteins through the formation of stable core complexes
description	Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quantities sufficient for structural and functional studies.
format	article
author	Nicolas Levy Sylvia Eiler Karine Pradeau-Aubreton Benoit Maillot François Stricher Marc Ruff
author_facet	Nicolas Levy Sylvia Eiler Karine Pradeau-Aubreton Benoit Maillot François Stricher Marc Ruff
author_sort	Nicolas Levy
title	Production of unstable proteins through the formation of stable core complexes
title_short	Production of unstable proteins through the formation of stable core complexes
title_full	Production of unstable proteins through the formation of stable core complexes
title_fullStr	Production of unstable proteins through the formation of stable core complexes
title_full_unstemmed	Production of unstable proteins through the formation of stable core complexes
title_sort	production of unstable proteins through the formation of stable core complexes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9ef95dc3bce44f668e21a106a000cf31
work_keys_str_mv	AT nicolaslevy productionofunstableproteinsthroughtheformationofstablecorecomplexes AT sylviaeiler productionofunstableproteinsthroughtheformationofstablecorecomplexes AT karinepradeauaubreton productionofunstableproteinsthroughtheformationofstablecorecomplexes AT benoitmaillot productionofunstableproteinsthroughtheformationofstablecorecomplexes AT francoisstricher productionofunstableproteinsthroughtheformationofstablecorecomplexes AT marcruff productionofunstableproteinsthroughtheformationofstablecorecomplexes
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Production of unstable proteins through the formation of stable core complexes

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