mTADA is a framework for identifying risk genes from de novo mutations in multiple traits

Joint analysis of multiple traits can increase power and provide insights into shared genetic architecture. Here, Nguyen et al. develop multi-trait TADA (mTADA), an extension of TADA (transmission and de novo association test) that jointly analyses de novo mutations of traits for improved risk-gene...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tan-Hoang Nguyen, Amanda Dobbyn, Ruth C. Brown, Brien P. Riley, Joseph D. Buxbaum, Dalila Pinto, Shaun M. Purcell, Patrick F. Sullivan, Xin He, Eli A. Stahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9efa27d972d143f4a615a8a3322d55ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9efa27d972d143f4a615a8a3322d55ba
record_format	dspace
spelling	oai:doaj.org-article:9efa27d972d143f4a615a8a3322d55ba2021-12-02T14:58:24ZmTADA is a framework for identifying risk genes from de novo mutations in multiple traits10.1038/s41467-020-16487-z2041-1723https://doaj.org/article/9efa27d972d143f4a615a8a3322d55ba2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16487-zhttps://doaj.org/toc/2041-1723Joint analysis of multiple traits can increase power and provide insights into shared genetic architecture. Here, Nguyen et al. develop multi-trait TADA (mTADA), an extension of TADA (transmission and de novo association test) that jointly analyses de novo mutations of traits for improved risk-gene identification power.Tan-Hoang NguyenAmanda DobbynRuth C. BrownBrien P. RileyJoseph D. BuxbaumDalila PintoShaun M. PurcellPatrick F. SullivanXin HeEli A. StahlNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tan-Hoang Nguyen Amanda Dobbyn Ruth C. Brown Brien P. Riley Joseph D. Buxbaum Dalila Pinto Shaun M. Purcell Patrick F. Sullivan Xin He Eli A. Stahl mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
description	Joint analysis of multiple traits can increase power and provide insights into shared genetic architecture. Here, Nguyen et al. develop multi-trait TADA (mTADA), an extension of TADA (transmission and de novo association test) that jointly analyses de novo mutations of traits for improved risk-gene identification power.
format	article
author	Tan-Hoang Nguyen Amanda Dobbyn Ruth C. Brown Brien P. Riley Joseph D. Buxbaum Dalila Pinto Shaun M. Purcell Patrick F. Sullivan Xin He Eli A. Stahl
author_facet	Tan-Hoang Nguyen Amanda Dobbyn Ruth C. Brown Brien P. Riley Joseph D. Buxbaum Dalila Pinto Shaun M. Purcell Patrick F. Sullivan Xin He Eli A. Stahl
author_sort	Tan-Hoang Nguyen
title	mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
title_short	mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
title_full	mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
title_fullStr	mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
title_full_unstemmed	mTADA is a framework for identifying risk genes from de novo mutations in multiple traits
title_sort	mtada is a framework for identifying risk genes from de novo mutations in multiple traits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9efa27d972d143f4a615a8a3322d55ba
work_keys_str_mv	AT tanhoangnguyen mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT amandadobbyn mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT ruthcbrown mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT brienpriley mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT josephdbuxbaum mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT dalilapinto mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT shaunmpurcell mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT patrickfsullivan mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT xinhe mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits AT eliastahl mtadaisaframeworkforidentifyingriskgenesfromdenovomutationsinmultipletraits
_version_	1718389281896005632

mTADA is a framework for identifying risk genes from de novo mutations in multiple traits

Ejemplares similares