TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

TGF-β is widely held to be critical for the maintenance and function of regulatory T (T(reg)) cells and thus peripheral tolerance. This is highlighted by constitutive ablation of TGF-β receptor (TR) during thymic development in mice, which leads to a lethal autoimmune syndrome. Here we describe that...

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Autores principales: Anna Sledzińska, Saskia Hemmers, Florian Mair, Oliver Gorka, Jürgen Ruland, Lynsey Fairbairn, Anja Nissler, Werner Müller, Ari Waisman, Burkhard Becher, Thorsten Buch
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/9efc6ada7857426e844de069ad67186a
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