Everolimus-eluting stents: update on current clinical studies

Dominic J Allocco, Anita A Joshi, Keith D DawkinsBoston Scientific Corporation, Natick, MA, USAAbstract: Everolimus-eluting stents (EES) have become the most commonly implanted coronary stents worldwide. This review describes and analyzes the clinical data supporting the use of EES, focusing primari...

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Autores principales:	Allocco DJ, Joshi AA, Dawkins KD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/9f0486b7a1564f68bdeed40109681f26
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spelling	oai:doaj.org-article:9f0486b7a1564f68bdeed40109681f262021-12-02T00:28:00ZEverolimus-eluting stents: update on current clinical studies1179-1470https://doaj.org/article/9f0486b7a1564f68bdeed40109681f262011-07-01T00:00:00Zhttp://www.dovepress.com/everolimus-eluting-stents-update-on-current-clinical-studies-a7950https://doaj.org/toc/1179-1470Dominic J Allocco, Anita A Joshi, Keith D DawkinsBoston Scientific Corporation, Natick, MA, USAAbstract: Everolimus-eluting stents (EES) have become the most commonly implanted coronary stents worldwide. This review describes and analyzes the clinical data supporting the use of EES, focusing primarily on published, randomized, controlled trials. Everolimuseluting stents have been shown to have less restenosis, stent thrombosis, and periprocedural myocardial infarction compared with earlier generation paclitaxel-eluting stents (PES). Lower rates of adverse events for EES compared with PES were generally seen in all subgroups, with the notable exception of patients with diabetes mellitus. There have been fewer, randomized, clinical trials comparing EES with either sirolimus-eluting stents or zotarolimus-eluting stents, although very good results with EES have been observed in the trials that have been performed. Recent clinical trial data suggest that this excellent safety and efficacy profile is maintained in a next-generation EES designed to have improved mechanical properties and radiopacity.Keywords: drug-eluting stents, everolimus, Xience V, Promus, Promus ElementVideo Abstract:&nbsp; http://dvpr.es/allocco &nbsp;Allocco DJJoshi AADawkins KDDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2011, Iss default, Pp 91-98 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Allocco DJ Joshi AA Dawkins KD Everolimus-eluting stents: update on current clinical studies
description	Dominic J Allocco, Anita A Joshi, Keith D DawkinsBoston Scientific Corporation, Natick, MA, USAAbstract: Everolimus-eluting stents (EES) have become the most commonly implanted coronary stents worldwide. This review describes and analyzes the clinical data supporting the use of EES, focusing primarily on published, randomized, controlled trials. Everolimuseluting stents have been shown to have less restenosis, stent thrombosis, and periprocedural myocardial infarction compared with earlier generation paclitaxel-eluting stents (PES). Lower rates of adverse events for EES compared with PES were generally seen in all subgroups, with the notable exception of patients with diabetes mellitus. There have been fewer, randomized, clinical trials comparing EES with either sirolimus-eluting stents or zotarolimus-eluting stents, although very good results with EES have been observed in the trials that have been performed. Recent clinical trial data suggest that this excellent safety and efficacy profile is maintained in a next-generation EES designed to have improved mechanical properties and radiopacity.Keywords: drug-eluting stents, everolimus, Xience V, Promus, Promus ElementVideo Abstract:&nbsp; http://dvpr.es/allocco &nbsp;
format	article
author	Allocco DJ Joshi AA Dawkins KD
author_facet	Allocco DJ Joshi AA Dawkins KD
author_sort	Allocco DJ
title	Everolimus-eluting stents: update on current clinical studies
title_short	Everolimus-eluting stents: update on current clinical studies
title_full	Everolimus-eluting stents: update on current clinical studies
title_fullStr	Everolimus-eluting stents: update on current clinical studies
title_full_unstemmed	Everolimus-eluting stents: update on current clinical studies
title_sort	everolimus-eluting stents: update on current clinical studies
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/9f0486b7a1564f68bdeed40109681f26
work_keys_str_mv	AT alloccodj everolimuselutingstentsupdateoncurrentclinicalstudies AT joshiaa everolimuselutingstentsupdateoncurrentclinicalstudies AT dawkinskd everolimuselutingstentsupdateoncurrentclinicalstudies
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Everolimus-eluting stents: update on current clinical studies

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