Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.

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Autores principales:	Constantin Cretu, Patricia Gee, Xiang Liu, Anant Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh, Andrew Cook, Melissa Jurica, Nicholas A. Larsen, Vladimir Pena
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f060ae1a19640e593633f074975b41b
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spelling	oai:doaj.org-article:9f060ae1a19640e593633f074975b41b2021-12-02T16:43:56ZStructural basis of intron selection by U2 snRNP in the presence of covalent inhibitors10.1038/s41467-021-24741-12041-1723https://doaj.org/article/9f060ae1a19640e593633f074975b41b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24741-1https://doaj.org/toc/2041-1723Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.Constantin CretuPatricia GeeXiang LiuAnant AgrawalTuong-Vi NguyenArun K. GhoshAndrew CookMelissa JuricaNicholas A. LarsenVladimir PenaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Constantin Cretu Patricia Gee Xiang Liu Anant Agrawal Tuong-Vi Nguyen Arun K. Ghosh Andrew Cook Melissa Jurica Nicholas A. Larsen Vladimir Pena Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
description	Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.
format	article
author	Constantin Cretu Patricia Gee Xiang Liu Anant Agrawal Tuong-Vi Nguyen Arun K. Ghosh Andrew Cook Melissa Jurica Nicholas A. Larsen Vladimir Pena
author_facet	Constantin Cretu Patricia Gee Xiang Liu Anant Agrawal Tuong-Vi Nguyen Arun K. Ghosh Andrew Cook Melissa Jurica Nicholas A. Larsen Vladimir Pena
author_sort	Constantin Cretu
title	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
title_short	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
title_full	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
title_fullStr	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
title_full_unstemmed	Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
title_sort	structural basis of intron selection by u2 snrnp in the presence of covalent inhibitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f060ae1a19640e593633f074975b41b
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Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

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