Distinct populations of cortical pyramidal neurons mediate drug reward and aversion

The anterior cingulate plays a role in addiction, but studies have not examined the role of its two types of glutamatergic projection neurons, pyramidal tract (PT) and intratelencephalic (IT). Here we demonstrate that these two populations regulate distinct features of a drug experience, its positiv...

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Autores principales:	A. F. Garcia, E. A. Crummy, I. G. Webb, M. N. Nooney, S. M. Ferguson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f06f37d4c464aeda18e14ff1ab6927f
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spelling	oai:doaj.org-article:9f06f37d4c464aeda18e14ff1ab6927f2021-12-02T11:56:18ZDistinct populations of cortical pyramidal neurons mediate drug reward and aversion10.1038/s41467-020-20526-02041-1723https://doaj.org/article/9f06f37d4c464aeda18e14ff1ab6927f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20526-0https://doaj.org/toc/2041-1723The anterior cingulate plays a role in addiction, but studies have not examined the role of its two types of glutamatergic projection neurons, pyramidal tract (PT) and intratelencephalic (IT). Here we demonstrate that these two populations regulate distinct features of a drug experience, its positive and negative aspects, respectively.A. F. GarciaE. A. CrummyI. G. WebbM. N. NooneyS. M. FergusonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. F. Garcia E. A. Crummy I. G. Webb M. N. Nooney S. M. Ferguson Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
description	The anterior cingulate plays a role in addiction, but studies have not examined the role of its two types of glutamatergic projection neurons, pyramidal tract (PT) and intratelencephalic (IT). Here we demonstrate that these two populations regulate distinct features of a drug experience, its positive and negative aspects, respectively.
format	article
author	A. F. Garcia E. A. Crummy I. G. Webb M. N. Nooney S. M. Ferguson
author_facet	A. F. Garcia E. A. Crummy I. G. Webb M. N. Nooney S. M. Ferguson
author_sort	A. F. Garcia
title	Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
title_short	Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
title_full	Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
title_fullStr	Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
title_full_unstemmed	Distinct populations of cortical pyramidal neurons mediate drug reward and aversion
title_sort	distinct populations of cortical pyramidal neurons mediate drug reward and aversion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f06f37d4c464aeda18e14ff1ab6927f
work_keys_str_mv	AT afgarcia distinctpopulationsofcorticalpyramidalneuronsmediatedrugrewardandaversion AT eacrummy distinctpopulationsofcorticalpyramidalneuronsmediatedrugrewardandaversion AT igwebb distinctpopulationsofcorticalpyramidalneuronsmediatedrugrewardandaversion AT mnnooney distinctpopulationsofcorticalpyramidalneuronsmediatedrugrewardandaversion AT smferguson distinctpopulationsofcorticalpyramidalneuronsmediatedrugrewardandaversion
_version_	1718394824280768512

Distinct populations of cortical pyramidal neurons mediate drug reward and aversion

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