Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis

Abstract Sulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements to improve weight management and reduce lipid levels. However, its effects on serum lipid profiles are contradictory. In this review, a meta-analysis and systemat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaili Du, Yuxin Fan, Dan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9f08f859a857403c9c2be652c45f0077
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f08f859a857403c9c2be652c45f0077
record_format	dspace
spelling	oai:doaj.org-article:9f08f859a857403c9c2be652c45f00772021-12-02T14:37:46ZSulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis10.1038/s41598-021-87367-92045-2322https://doaj.org/article/9f08f859a857403c9c2be652c45f00772021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87367-9https://doaj.org/toc/2045-2322Abstract Sulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements to improve weight management and reduce lipid levels. However, its effects on serum lipid profiles are contradictory. In this review, a meta-analysis and systematic review of SFN on lipid reduction and weight control is assessed with mice and rats fed on high-fat diet. The effects of SFN supplementation were evaluated by weighted mean difference (WMD) in body weight (BW), liver weight (LW) and also by its effect on serum lipids. A random-effects model was applied to estimate the overall summary effect. SFN reduced BW (WMD: − 2.76 g, 95% CI: − 4.19, − 1.34) and LW (WMD: − 0.93 g, 95% CI: − 1.63, − 0.23) significantly in our ten trials. Its effects on serum total cholesterol (TC) (WMD: − 15.62 mg/dL, 95% CI: − 24.07, − 7.18), low-density lipoprotein cholesterol (LDL-C) (WMD: − 8.35 mg/dL, 95% CI: − 15.47, − 1.24) and triglyceride (TG) (WMD: − 40.85 mg/dL, 95% CI: − 67.46, − 14.24) were significant except for high-density lipoprotein cholesterol (HDL-C) component (WMD: 1.05 mg/dL, 95% CI: − 3.44, 5.54). However, species, disease model, duration, SFN dosage as well as route of administration did not explain the heterogeneity among studies. In summary, these findings provide new insights concerning preclinical strategies for treating diseases including obesity, diabetes, hypertension, non-alcoholic fatty liver disease as well as cardiovascular disease with SFN supplements.Kaili DuYuxin FanDan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaili Du Yuxin Fan Dan Li Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
description	Abstract Sulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements to improve weight management and reduce lipid levels. However, its effects on serum lipid profiles are contradictory. In this review, a meta-analysis and systematic review of SFN on lipid reduction and weight control is assessed with mice and rats fed on high-fat diet. The effects of SFN supplementation were evaluated by weighted mean difference (WMD) in body weight (BW), liver weight (LW) and also by its effect on serum lipids. A random-effects model was applied to estimate the overall summary effect. SFN reduced BW (WMD: − 2.76 g, 95% CI: − 4.19, − 1.34) and LW (WMD: − 0.93 g, 95% CI: − 1.63, − 0.23) significantly in our ten trials. Its effects on serum total cholesterol (TC) (WMD: − 15.62 mg/dL, 95% CI: − 24.07, − 7.18), low-density lipoprotein cholesterol (LDL-C) (WMD: − 8.35 mg/dL, 95% CI: − 15.47, − 1.24) and triglyceride (TG) (WMD: − 40.85 mg/dL, 95% CI: − 67.46, − 14.24) were significant except for high-density lipoprotein cholesterol (HDL-C) component (WMD: 1.05 mg/dL, 95% CI: − 3.44, 5.54). However, species, disease model, duration, SFN dosage as well as route of administration did not explain the heterogeneity among studies. In summary, these findings provide new insights concerning preclinical strategies for treating diseases including obesity, diabetes, hypertension, non-alcoholic fatty liver disease as well as cardiovascular disease with SFN supplements.
format	article
author	Kaili Du Yuxin Fan Dan Li
author_facet	Kaili Du Yuxin Fan Dan Li
author_sort	Kaili Du
title	Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
title_short	Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
title_full	Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
title_fullStr	Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
title_full_unstemmed	Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
title_sort	sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f08f859a857403c9c2be652c45f0077
work_keys_str_mv	AT kailidu sulforaphaneameliorateslipidprofileinrodentsanupdatedsystematicreviewandmetaanalysis AT yuxinfan sulforaphaneameliorateslipidprofileinrodentsanupdatedsystematicreviewandmetaanalysis AT danli sulforaphaneameliorateslipidprofileinrodentsanupdatedsystematicreviewandmetaanalysis
_version_	1718390968171888640

Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis

Ejemplares similares