Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study

Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study

Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed lung cancer and is associated with poor prognosis. This study aimed to analyze if serum C-reactive protein (CRP), albumin (Alb), and CRP/Alb ratio could provide prognostic information in patients with NSCLC. 387 patients with...

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Autores principales: Jin-Rong Yang, Jia-Ying Xu, Guo-Chong Chen, Na Yu, Jing Yang, Da-Xiong Zeng, Min-Jing Gu, Da-Peng Li, Yu-Song Zhang, Li-Qiang Qin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/9f0b4725be314b2ea1e9221bd97fc64b
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spelling oai:doaj.org-article:9f0b4725be314b2ea1e9221bd97fc64b2021-12-02T15:09:58ZPost-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study10.1038/s41598-019-44653-x2045-2322https://doaj.org/article/9f0b4725be314b2ea1e9221bd97fc64b2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44653-xhttps://doaj.org/toc/2045-2322Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed lung cancer and is associated with poor prognosis. This study aimed to analyze if serum C-reactive protein (CRP), albumin (Alb), and CRP/Alb ratio could provide prognostic information in patients with NSCLC. 387 patients with primary NSCLC were included in this analysis. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95% confidence interval (CI) of death with adjustment for some potential confounders. The multivariate regression analyses revealed the statistically significant associations of decreased survival of patients with NSCLC with elevated CRP, decreased Alb, and elevated CRP/Alb ratio. The HRs of mortality were 1.56 (95% CI: 0.80–3.04) and 2.64 (95% CI: 1.35–5.16) for patients in the second and the highest tertiles of CRP (P-trend = 0.003). For albumin, the HR was 0.50 (95% CI: 0.29–0.85) for the normal group. The CRP/Alb ratio strongly predicted the survival of patients in the highest tertile with a fourfold risk of dying compared with those in the lowest tertile (HR = 4.14, 95% CI: 2.15–7.98). The subgroup analysis according to various patient characteristics confirmed these associations. In conclusion, serum CRP, albumin, and CRP/Alb ratio are predictive of survival for Chinese patients with NSCLC.Jin-Rong YangJia-Ying XuGuo-Chong ChenNa YuJing YangDa-Xiong ZengMin-Jing GuDa-Peng LiYu-Song ZhangLi-Qiang QinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jin-Rong Yang
Jia-Ying Xu
Guo-Chong Chen
Na Yu
Jing Yang
Da-Xiong Zeng
Min-Jing Gu
Da-Peng Li
Yu-Song Zhang
Li-Qiang Qin
Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
description Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed lung cancer and is associated with poor prognosis. This study aimed to analyze if serum C-reactive protein (CRP), albumin (Alb), and CRP/Alb ratio could provide prognostic information in patients with NSCLC. 387 patients with primary NSCLC were included in this analysis. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95% confidence interval (CI) of death with adjustment for some potential confounders. The multivariate regression analyses revealed the statistically significant associations of decreased survival of patients with NSCLC with elevated CRP, decreased Alb, and elevated CRP/Alb ratio. The HRs of mortality were 1.56 (95% CI: 0.80–3.04) and 2.64 (95% CI: 1.35–5.16) for patients in the second and the highest tertiles of CRP (P-trend = 0.003). For albumin, the HR was 0.50 (95% CI: 0.29–0.85) for the normal group. The CRP/Alb ratio strongly predicted the survival of patients in the highest tertile with a fourfold risk of dying compared with those in the lowest tertile (HR = 4.14, 95% CI: 2.15–7.98). The subgroup analysis according to various patient characteristics confirmed these associations. In conclusion, serum CRP, albumin, and CRP/Alb ratio are predictive of survival for Chinese patients with NSCLC.
format article
author Jin-Rong Yang
Jia-Ying Xu
Guo-Chong Chen
Na Yu
Jing Yang
Da-Xiong Zeng
Min-Jing Gu
Da-Peng Li
Yu-Song Zhang
Li-Qiang Qin
author_facet Jin-Rong Yang
Jia-Ying Xu
Guo-Chong Chen
Na Yu
Jing Yang
Da-Xiong Zeng
Min-Jing Gu
Da-Peng Li
Yu-Song Zhang
Li-Qiang Qin
author_sort Jin-Rong Yang
title Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
title_short Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
title_full Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
title_fullStr Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
title_full_unstemmed Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study
title_sort post-diagnostic c-reactive protein and albumin predict survival in chinese patients with non-small cell lung cancer: a prospective cohort study
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9f0b4725be314b2ea1e9221bd97fc64b
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