Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular cor...

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Autores principales:	Amar Singh, Sabarinathan Ramachandran, Melanie L. Graham, Saeed Daneshmandi, David Heller, Wilma Lucia Suarez-Pinzon, Appakalai N. Balamurugan, Jeffrey D. Ansite, Joshua J. Wilhelm, Amy Yang, Ying Zhang, Nagendra P. Palani, Juan E. Abrahante, Christopher Burlak, Stephen D. Miller, Xunrong Luo, Bernhard J. Hering
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f12512e066c4896a761008ae6935b13
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spelling	oai:doaj.org-article:9f12512e066c4896a761008ae6935b132021-12-02T16:57:07ZLong-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes10.1038/s41467-019-11338-y2041-1723https://doaj.org/article/9f12512e066c4896a761008ae6935b132019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11338-yhttps://doaj.org/toc/2041-1723Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular correlates of tolerance induction.Amar SinghSabarinathan RamachandranMelanie L. GrahamSaeed DaneshmandiDavid HellerWilma Lucia Suarez-PinzonAppakalai N. BalamuruganJeffrey D. AnsiteJoshua J. WilhelmAmy YangYing ZhangNagendra P. PalaniJuan E. AbrahanteChristopher BurlakStephen D. MillerXunrong LuoBernhard J. HeringNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amar Singh Sabarinathan Ramachandran Melanie L. Graham Saeed Daneshmandi David Heller Wilma Lucia Suarez-Pinzon Appakalai N. Balamurugan Jeffrey D. Ansite Joshua J. Wilhelm Amy Yang Ying Zhang Nagendra P. Palani Juan E. Abrahante Christopher Burlak Stephen D. Miller Xunrong Luo Bernhard J. Hering Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
description	Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular correlates of tolerance induction.
format	article
author	Amar Singh Sabarinathan Ramachandran Melanie L. Graham Saeed Daneshmandi David Heller Wilma Lucia Suarez-Pinzon Appakalai N. Balamurugan Jeffrey D. Ansite Joshua J. Wilhelm Amy Yang Ying Zhang Nagendra P. Palani Juan E. Abrahante Christopher Burlak Stephen D. Miller Xunrong Luo Bernhard J. Hering
author_facet	Amar Singh Sabarinathan Ramachandran Melanie L. Graham Saeed Daneshmandi David Heller Wilma Lucia Suarez-Pinzon Appakalai N. Balamurugan Jeffrey D. Ansite Joshua J. Wilhelm Amy Yang Ying Zhang Nagendra P. Palani Juan E. Abrahante Christopher Burlak Stephen D. Miller Xunrong Luo Bernhard J. Hering
author_sort	Amar Singh
title	Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
title_short	Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
title_full	Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
title_fullStr	Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
title_full_unstemmed	Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
title_sort	long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9f12512e066c4896a761008ae6935b13
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Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

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