Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular cor...

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Main Authors: Amar Singh, Sabarinathan Ramachandran, Melanie L. Graham, Saeed Daneshmandi, David Heller, Wilma Lucia Suarez-Pinzon, Appakalai N. Balamurugan, Jeffrey D. Ansite, Joshua J. Wilhelm, Amy Yang, Ying Zhang, Nagendra P. Palani, Juan E. Abrahante, Christopher Burlak, Stephen D. Miller, Xunrong Luo, Bernhard J. Hering
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/9f12512e066c4896a761008ae6935b13
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https://doaj.org/article/9f12512e066c4896a761008ae6935b13

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