miRNA-21 as a novel therapeutic target in lung cancer

Athina Markou, Martha Zavridou, Evi S LianidouAnalysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, GreeceAbstract: Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for th...

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Autores principales:	Markou A, Zavridou M, Lianidou ES
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	lung cancer miR-21 therapeutic target NSCLC response to therapy. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9f12b5a6c1d848f18754a272b4f21f47
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id	oai:doaj.org-article:9f12b5a6c1d848f18754a272b4f21f47
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spelling	oai:doaj.org-article:9f12b5a6c1d848f18754a272b4f21f472021-12-02T07:10:42ZmiRNA-21 as a novel therapeutic target in lung cancer1179-2728https://doaj.org/article/9f12b5a6c1d848f18754a272b4f21f472016-03-01T00:00:00Zhttps://www.dovepress.com/mirna-21-as-a-novel-therapeutic-target-in-lung-cancer-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Athina Markou, Martha Zavridou, Evi S LianidouAnalysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, GreeceAbstract: Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker research, in diagnosis, and in therapy. In this review we focus on miR-21 in lung cancer and especially on how miR-21 is involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic target.Keywords: lung cancer, miR-21, therapeutic target, NSCLC, response to therapyMarkou AZavridou MLianidou ESDove Medical Pressarticlelung cancermiR-21therapeutic targetNSCLCresponse to therapy.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 19-27 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer miR-21 therapeutic target NSCLC response to therapy. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lung cancer miR-21 therapeutic target NSCLC response to therapy. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Markou A Zavridou M Lianidou ES miRNA-21 as a novel therapeutic target in lung cancer
description	Athina Markou, Martha Zavridou, Evi S LianidouAnalysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, GreeceAbstract: Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker research, in diagnosis, and in therapy. In this review we focus on miR-21 in lung cancer and especially on how miR-21 is involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic target.Keywords: lung cancer, miR-21, therapeutic target, NSCLC, response to therapy
format	article
author	Markou A Zavridou M Lianidou ES
author_facet	Markou A Zavridou M Lianidou ES
author_sort	Markou A
title	miRNA-21 as a novel therapeutic target in lung cancer
title_short	miRNA-21 as a novel therapeutic target in lung cancer
title_full	miRNA-21 as a novel therapeutic target in lung cancer
title_fullStr	miRNA-21 as a novel therapeutic target in lung cancer
title_full_unstemmed	miRNA-21 as a novel therapeutic target in lung cancer
title_sort	mirna-21 as a novel therapeutic target in lung cancer
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/9f12b5a6c1d848f18754a272b4f21f47
work_keys_str_mv	AT markoua mirna21asanoveltherapeutictargetinlungcancer AT zavridoum mirna21asanoveltherapeutictargetinlungcancer AT lianidoues mirna21asanoveltherapeutictargetinlungcancer
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miRNA-21 as a novel therapeutic target in lung cancer

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