Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria

Abstract Background Regular evaluation of antimicrobials prescriptions is important for optimal use. Objective This study determined the prescription patterns, class and costs of antimicrobials in the adult out-patient pharmacy of a Teaching Hospital in Nigeria. Methods A 1-year retrospective study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angus Nnamdi Oli, Nwanneka Onyeaso, Stephen Chijioke Emencheta, Chijioke M. Ofomata, James-Paul Kretchy, Augustine Okhamafe, Grace N. Ele
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pharmacy practice Antimicrobial use Rational prescribing Essential drug list Drug utilization Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/9f15e105aa29476ca0f12927c98b5789
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f15e105aa29476ca0f12927c98b5789
record_format	dspace
spelling	oai:doaj.org-article:9f15e105aa29476ca0f12927c98b57892021-12-05T12:04:03ZEvaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria10.1186/s40545-021-00380-12052-3211https://doaj.org/article/9f15e105aa29476ca0f12927c98b57892021-11-01T00:00:00Zhttps://doi.org/10.1186/s40545-021-00380-1https://doaj.org/toc/2052-3211Abstract Background Regular evaluation of antimicrobials prescriptions is important for optimal use. Objective This study determined the prescription patterns, class and costs of antimicrobials in the adult out-patient pharmacy of a Teaching Hospital in Nigeria. Methods A 1-year retrospective study from 1st January to 31st December 2018. The data, which included identification code, age, sex, antibiotics prescribed, number of antibiotics per prescription, number of medicines per prescription, dosage form, generic prescribing, drug on the essential drug list, and cost, were used in the analysis. The Chi-square test and Analysis of Variance were used to compare our data with the WHO–developed antimicrobial prescription Guidelines for Anatomical Therapeutic Chemical and Defined Daily Dose assignment of 2019. Results From 450 patient records, significantly more females (70%) were prescribed with antimicrobials (P = 0.0038). The prescription pattern showed that antimicrobials selection by class was significantly different (P < 0.0001) (top three being Amino-penicillin > Nitroimidazoles > Fluoroquinolone). In addition, age differed significantly (P < 0.0001) with 46–50 as the highest class. Dosage forms profile showed that the percentage of encounter with injections prescribed (1.8%) was less than WHO recommendation (13.4–24.1%). Most of the prescriptions (84.22%) were from the Essential Drug List. The average cost of prescriptions with two antimicrobials was the highest ($14.0807), then three ($10.7949), and one ($6.39858). The average number of drugs per prescription that had one (4.28), two (4.46), and three (5.55) antimicrobials, respectively, were more than double the average (2) recommended by WHO. Conclusion The study showed that most of the patterns are within limit, however, highlights the need for frequent evaluation.Angus Nnamdi OliNwanneka OnyeasoStephen Chijioke EmenchetaChijioke M. OfomataJames-Paul KretchyAugustine OkhamafeGrace N. EleBMCarticlePharmacy practiceAntimicrobial useRational prescribingEssential drug listDrug utilizationTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmaceutical Policy and Practice, Vol 14, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pharmacy practice Antimicrobial use Rational prescribing Essential drug list Drug utilization Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Pharmacy practice Antimicrobial use Rational prescribing Essential drug list Drug utilization Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Angus Nnamdi Oli Nwanneka Onyeaso Stephen Chijioke Emencheta Chijioke M. Ofomata James-Paul Kretchy Augustine Okhamafe Grace N. Ele Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
description	Abstract Background Regular evaluation of antimicrobials prescriptions is important for optimal use. Objective This study determined the prescription patterns, class and costs of antimicrobials in the adult out-patient pharmacy of a Teaching Hospital in Nigeria. Methods A 1-year retrospective study from 1st January to 31st December 2018. The data, which included identification code, age, sex, antibiotics prescribed, number of antibiotics per prescription, number of medicines per prescription, dosage form, generic prescribing, drug on the essential drug list, and cost, were used in the analysis. The Chi-square test and Analysis of Variance were used to compare our data with the WHO–developed antimicrobial prescription Guidelines for Anatomical Therapeutic Chemical and Defined Daily Dose assignment of 2019. Results From 450 patient records, significantly more females (70%) were prescribed with antimicrobials (P = 0.0038). The prescription pattern showed that antimicrobials selection by class was significantly different (P < 0.0001) (top three being Amino-penicillin > Nitroimidazoles > Fluoroquinolone). In addition, age differed significantly (P < 0.0001) with 46–50 as the highest class. Dosage forms profile showed that the percentage of encounter with injections prescribed (1.8%) was less than WHO recommendation (13.4–24.1%). Most of the prescriptions (84.22%) were from the Essential Drug List. The average cost of prescriptions with two antimicrobials was the highest ($14.0807), then three ($10.7949), and one ($6.39858). The average number of drugs per prescription that had one (4.28), two (4.46), and three (5.55) antimicrobials, respectively, were more than double the average (2) recommended by WHO. Conclusion The study showed that most of the patterns are within limit, however, highlights the need for frequent evaluation.
format	article
author	Angus Nnamdi Oli Nwanneka Onyeaso Stephen Chijioke Emencheta Chijioke M. Ofomata James-Paul Kretchy Augustine Okhamafe Grace N. Ele
author_facet	Angus Nnamdi Oli Nwanneka Onyeaso Stephen Chijioke Emencheta Chijioke M. Ofomata James-Paul Kretchy Augustine Okhamafe Grace N. Ele
author_sort	Angus Nnamdi Oli
title	Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
title_short	Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
title_full	Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
title_fullStr	Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
title_full_unstemmed	Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria
title_sort	evaluating antimicrobial prescribing in a tertiary healthcare institution in nigeria
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9f15e105aa29476ca0f12927c98b5789
work_keys_str_mv	AT angusnnamdioli evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT nwannekaonyeaso evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT stephenchijiokeemencheta evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT chijiokemofomata evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT jamespaulkretchy evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT augustineokhamafe evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria AT gracenele evaluatingantimicrobialprescribinginatertiaryhealthcareinstitutioninnigeria
_version_	1718372273883185152

Evaluating antimicrobial prescribing in a Tertiary Healthcare Institution in Nigeria

Ejemplares similares