Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant driv...

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Autores principales:	Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d
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spelling	oai:doaj.org-article:9f1676662817487ea864a82ec0a5a86d2021-12-02T17:31:41ZEndogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency10.1038/s41467-020-14638-w2041-1723https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14638-whttps://doaj.org/toc/2041-1723The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours.Alejandro Álvarez-QuilónJosé Terrón-BautistaIrene Delgado-SainzAlmudena Serrano-BenítezRocío Romero-GranadosPedro Manuel Martínez-GarcíaSilvia Jimeno-GonzálezCristina Bernal-LozanoCristina QuinteroLourdes García-QuintanillaFelipe Cortés-LedesmaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alejandro Álvarez-Quilón José Terrón-Bautista Irene Delgado-Sainz Almudena Serrano-Benítez Rocío Romero-Granados Pedro Manuel Martínez-García Silvia Jimeno-González Cristina Bernal-Lozano Cristina Quintero Lourdes García-Quintanilla Felipe Cortés-Ledesma Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
description	The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies. Here, the authors develop a Tdp2 −/− Atm −/− double-deficient mouse model to uncover topoisomerase II-induced DSBs as significant drivers of the genomic rearrangements that underpin these tumours.
format	article
author	Alejandro Álvarez-Quilón José Terrón-Bautista Irene Delgado-Sainz Almudena Serrano-Benítez Rocío Romero-Granados Pedro Manuel Martínez-García Silvia Jimeno-González Cristina Bernal-Lozano Cristina Quintero Lourdes García-Quintanilla Felipe Cortés-Ledesma
author_facet	Alejandro Álvarez-Quilón José Terrón-Bautista Irene Delgado-Sainz Almudena Serrano-Benítez Rocío Romero-Granados Pedro Manuel Martínez-García Silvia Jimeno-González Cristina Bernal-Lozano Cristina Quintero Lourdes García-Quintanilla Felipe Cortés-Ledesma
author_sort	Alejandro Álvarez-Quilón
title	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
title_short	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
title_full	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
title_fullStr	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
title_full_unstemmed	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
title_sort	endogenous topoisomerase ii-mediated dna breaks drive thymic cancer predisposition linked to atm deficiency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9f1676662817487ea864a82ec0a5a86d
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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

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