Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment

Zaher Armaly, Joseph Farah, Adel Jabbour, Bishara Bisharat, Amir Abd-El Qader, Shahira Saba, Maha Zaher, Elia El Haj, Munir Hamzi, Abdalla BowirratThe Nazareth Hospital, Hospital Affiliated with Galilee Medical School-Bar Ilan University, Zefat, IsraelObjective: Depression illnesses are commonly obs...

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Autores principales:	Armaly Z, Farah J, Jabbour A, Bisharat B, Abd-El Qader A, Saba S, Zaher M, El Haj E, Hamzi M, Bowirrat A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9f1eccfe4b38438ab8300f99df97a071
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spelling	oai:doaj.org-article:9f1eccfe4b38438ab8300f99df97a0712021-12-02T06:46:36ZMajor depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment1176-63281178-2021https://doaj.org/article/9f1eccfe4b38438ab8300f99df97a0712012-07-01T00:00:00Zhttp://www.dovepress.com/major-depressive-disorders-in-chronic-hemodialysis-patients-in-nazaret-a10507https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Zaher Armaly, Joseph Farah, Adel Jabbour, Bishara Bisharat, Amir Abd-El Qader, Shahira Saba, Maha Zaher, Elia El Haj, Munir Hamzi, Abdalla BowirratThe Nazareth Hospital, Hospital Affiliated with Galilee Medical School-Bar Ilan University, Zefat, IsraelObjective: Depression illnesses are commonly observed in hemodialysis (HD) patients, which can influence the quality of life of end-stage renal disease patients. We evaluate the prevalence and predictive risk factors of depression in the Arab population undergoing HD in Nazareth, Israel.Methods: We conducted a prospective study that included 71 patients in the HD unit with a mean age of 61.9 &plusmn; 14.13 years who had undergone HD and 26 healthy control subjects with a mean age of 59.3 &plusmn; 7.3. Beck&#39;s Depression Inventory and Hamilton Depression Scale assessments were administered. Blood analysis for hematological and biochemical parameters was obtained. Diagnosis was made using the Diagnostic and Statistical Manual of Mental Disorders scale to correlate psychological variables with clinical, hematological, and biochemical parameters. Statistical analysis was carried out using analysis of variance followed by Tukey post-hoc multiple comparison tests.Results: The prevalence of depression was 43.7% in HD patients. Between HD patients and controls, cortisol values were 16.96 &plusmn; 0.5476 and 11.96 &plusmn; 1.116, respectively (P &lt; 0.0001; 95% confidence intervals [CI]: 2.416&ndash;6.825). Between depressed HD patients versus control subjects, cortisol values were 16.48 &plusmn; 0.72 and 11.96 &plusmn; 1.116, respectively (P = 0.0013; 95% CI: 1.878&ndash;7.184). Hematological and biochemical parameters were compared between depressed HD and nondepressed patients, but differences between the two groups were found to be insignificant (P &gt; 0.05).Conclusion: Our HD patients were severely depressed. Studies of glucocorticoid turnover activity such as cortisol, a potent chemical stress hormone, may be used as a model and marker for early diagnosis of depression among HD patients. The strong familial support system in Arabic traditions has failed to decrease depression among these patients.Keywords: Beck Depression Inventory, cortisol, depression, hemodialysisArmaly ZFarah JJabbour ABisharat BAbd-El Qader ASaba SZaher MEl Haj EHamzi MBowirrat ADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 329-338 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Armaly Z Farah J Jabbour A Bisharat B Abd-El Qader A Saba S Zaher M El Haj E Hamzi M Bowirrat A Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
description	Zaher Armaly, Joseph Farah, Adel Jabbour, Bishara Bisharat, Amir Abd-El Qader, Shahira Saba, Maha Zaher, Elia El Haj, Munir Hamzi, Abdalla BowirratThe Nazareth Hospital, Hospital Affiliated with Galilee Medical School-Bar Ilan University, Zefat, IsraelObjective: Depression illnesses are commonly observed in hemodialysis (HD) patients, which can influence the quality of life of end-stage renal disease patients. We evaluate the prevalence and predictive risk factors of depression in the Arab population undergoing HD in Nazareth, Israel.Methods: We conducted a prospective study that included 71 patients in the HD unit with a mean age of 61.9 &plusmn; 14.13 years who had undergone HD and 26 healthy control subjects with a mean age of 59.3 &plusmn; 7.3. Beck&#39;s Depression Inventory and Hamilton Depression Scale assessments were administered. Blood analysis for hematological and biochemical parameters was obtained. Diagnosis was made using the Diagnostic and Statistical Manual of Mental Disorders scale to correlate psychological variables with clinical, hematological, and biochemical parameters. Statistical analysis was carried out using analysis of variance followed by Tukey post-hoc multiple comparison tests.Results: The prevalence of depression was 43.7% in HD patients. Between HD patients and controls, cortisol values were 16.96 &plusmn; 0.5476 and 11.96 &plusmn; 1.116, respectively (P &lt; 0.0001; 95% confidence intervals [CI]: 2.416&ndash;6.825). Between depressed HD patients versus control subjects, cortisol values were 16.48 &plusmn; 0.72 and 11.96 &plusmn; 1.116, respectively (P = 0.0013; 95% CI: 1.878&ndash;7.184). Hematological and biochemical parameters were compared between depressed HD and nondepressed patients, but differences between the two groups were found to be insignificant (P &gt; 0.05).Conclusion: Our HD patients were severely depressed. Studies of glucocorticoid turnover activity such as cortisol, a potent chemical stress hormone, may be used as a model and marker for early diagnosis of depression among HD patients. The strong familial support system in Arabic traditions has failed to decrease depression among these patients.Keywords: Beck Depression Inventory, cortisol, depression, hemodialysis
format	article
author	Armaly Z Farah J Jabbour A Bisharat B Abd-El Qader A Saba S Zaher M El Haj E Hamzi M Bowirrat A
author_facet	Armaly Z Farah J Jabbour A Bisharat B Abd-El Qader A Saba S Zaher M El Haj E Hamzi M Bowirrat A
author_sort	Armaly Z
title	Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
title_short	Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
title_full	Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
title_fullStr	Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
title_full_unstemmed	Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment
title_sort	major depressive disorders in chronic hemodialysis patients in nazareth: identification and assessment
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9f1eccfe4b38438ab8300f99df97a071
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Major depressive disorders in chronic hemodialysis patients in Nazareth: identification and assessment

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